About: Boanmycin Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Boanmycin Hydrochloride
rdfs:subClassOf
Semantic_Type
  • Antibiotic
Preferred_Name
  • Boanmycin Hydrochloride
NCI_META_CUI
  • CL437181
PDQ_Open_Trial_Search_ID
  • 738501
PDQ_Closed_Trial_Search_ID
  • 738501
FULL_SYN
  • Bleomycin A6 HydrochlorideSYNCINSC0125066
  • Boanmycin HydrochloridePTNCI
  • BAM HClABNCI
DEFINITION
  • The hydrochloride salt form of boanmycin (aka bleomycin A6), a component of the antibiotic bleomycin produced by Streptomyces species, with potential antineoplastic activity. Upon administration, boanmycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals. This causes single- and double-stranded DNA breaks which eventually leads to cell death. Compared to bleomycin, boanmycin appears to have a more favorable toxicity profile.NCI
code
  • C102878
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