About: Recombinant Dimeric Filgrastim Fusion Protein F627

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Attributes	Values
rdf:type	Class
rdfs:label	Recombinant Dimeric Filgrastim Fusion Protein F627
rdfs:subClassOf	Recombinant Colony Stimulating Factor
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Recombinant Dimeric Filgrastim Fusion Protein F627
NCI_META_CUI	CL437135
PDQ_Open_Trial_Search_ID	737722
PDQ_Closed_Trial_Search_ID	737722
FULL_SYN	Recombinant Dimeric G-CSF Fusion Protein F627SYNCI F627CNNCI Recombinant Dimeric Filgrastim Fusion Protein F627PTNCI
DEFINITION	A recombinant dimeric fusion peptide of the human granulocyte colony-stimulating factor (G-CSF; filgrastim), with immunomodulating and hematopoietic activities. Recombinant dimeric filgrastim fusion protein F627 binds to the cell surface G-CSF receptors (G-CSFRs) inducing receptor dimerization and activation of signaling cascades such as the Jak-STAT and mitogen-activated protein kinase pathways. This stimulates neutrophil progenitor proliferation and differentiation. Compared to other preparations of monomer recombinant G-CSF, dimeric filgrastim may allow for stronger activation of G-CSFRs and a faster myeloid precursor response thus enhancing neutrophil recovery upon myelosuppressive therapy.NCI
code	C102854

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