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| - Tumours in children patients differ from those in adults, not only in the range of the various types of malignities and their biology, but also in the therapies used and the outcomes thereof. Today, paediatric haematology and oncology is thereforeconsidered an independent scientific and medicinal discipline. The dissimilarity of the biological properties of the malignities in childhood and adulthood, as well as the difference between the respective treatmentprocedures and/or preferences can be demonstrated by the fact that, the few negligible exceptions notwithstanding, children patients are treated using different protocols from those employed in adults (e.g. acute leukaemias, lymphomes). (en)
- Nádorová onemocnění jsou druhou nejčastější příčinou úmrtí v dětském věku. Cílem tohoto projektu je dosažení pokroku v poznání etiologie a patogenese dětských maligních nádorových onemocnění a přenesení těchto výsledků do diagnostické a léčebné praxe.Projekt funkčně propojí léčebnou a výzkumnou základnu v oboru dětské onkologie na Universitě Karlově. Předmětem komplexního výzkumu budou dětské leukemie a nejčastější typy solidních nádorů dětského věku.Cílem projektu je zavedení nových imunologických a molekulárně genetických vyšetřovacích metod, vyhledávání a zkoumání nových markerů a zkoumání funkce a poruch signálních drah, onkogenů a buněčných enzymatických pochodů u dětských nádorových onemocnění.
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| Title
| - The Molecular Basis of Childhood Malignancies and Therapeutic Applications (en)
- Molekulární základy dětských nádorových onemocnění a léčebné aplikace
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ez/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...vavai/cez/dodavka
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| http://linked.open...ez/duvernostUdaju
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| http://linked.open...in/vavai/cez/faze
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| http://linked.open...ai/cez/hlavniObor
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| http://linked.open...vai/cez/hodnoceni
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| http://linked.open.../cez/kategorieVaV
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| http://linked.open.../cez/klicovaSlova
| - Childhood Malignancies; Tumours; children patients (en)
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| http://linked.open...cez/partnerHlavni
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| http://linked.open...z/poceVysledkuRIV
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cez/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open.../vavai/cez/resort
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ez/ukonceniReseni
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| http://linked.open.../cez/vedlejsiObor
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| http://linked.open...ez/zahajeniReseni
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| http://linked.open...n/vavai/cez/zamer
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| http://linked.open...sledkuDodavatelem
| - The research project represents an unique example of the well-focused support of very good laboratories. Professor Stary teams had a clear orientation at the time of research project formulation but the finantial support stabilized zoung researchers and increased number of diagnostic methods. It is an unique example when the substantial diagnostic progress has instantly reflected in the successful (en)
- Výzkumný záměr je vynikajícím příkladem cílené podpory špičkových laboratoří. Týmy prof. Starého měly své jasné směrování již v době formulování výzkumného záměru, ale finanční podpora stabilizovala mladé vědce a umožnila rozšířit paletu jedinečných diagnostických metod. Je opravdu jedinečné, že evidentní pokrok v diagnostice se bezprostředně odrazil v podstatném nárůstu úspěšnosti léčby. Zcela mi (cs)
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| http://linked.open...cez/zivotniCyklus
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| is http://linked.open...n/vavai/riv/zamer
of | - Acute Leukemias with ETV6/ABL1 (TEL/ABL) Fusion: Poor Prognosis and Prenatal Origin
- Comparison of Metallothionein Detection by Using Brdicka Reaction and Enzyme-Linked Immunosorbent Assay Employing Chicken Yolk Antibodies
- Firefly luciferase gene contains a cryptic promoter
- The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells
- Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells
- Molekulárně cytogenetická charakteristika feochromocytomu
- Long-term results of treatment of childhood acute lymphoblastic leukemia in the Czech Republic
- Detection and clinical significance of bone marrow involvement in patients with rhabdomyosarcoma.
- Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma
- ETV6/RUNX1 (TEL/AML1) is a frequent prenatal first hit in childhood leukemia
- Increased sperm aneuploidy in two male carriers of germline TP53 mutations
- The Relapsed AML 2001/01, 02 Study for children with relapsed acute myeloid leukaemia or initially resistant disease has improved outcome
- Molecular Cytogenetic Characterization in Four Pediatric Pheochromocytomas and Paragangliomas
- Revealing the role of TEL/AML1 for leukemic cell survival by RNAi-mediated silencing
- Second induction with high-dose cytarabine and mitoxantrone: different impact on pediatric AML patients with t(8;21) and with inv(16)
- Rhabdomyosarcoma: molecular analysis of Igf2, MyoD1 and Myogenin expression
- Up-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signaling
- An automated analysis of highly complex flow cytometry-based proteomic data
- The adaptor protein NTAL enhances proximal signaling and potentiates corticosteroid-induced apoptosis in T-ALL
- Comparison of the cytotoxicity of and DNA adduct formation by the anticancer drug ellipticine in human breast adenocarcinoma, leukemia and neuroblastoma cells
- Prenatal origin of childhood AML occurs less frequently than in childhood ALL
- Reovirus - possible therapy of cancer
- Familiární hemofagocytující lymfohistiocytóza způsobená deficiencí perforinu může být úspěšně léčená transplantací kmenových buněk krvetvroby - první případ diagnostikovaný v ČR
- IRESite: the database of experimentally verified IRES structures (www.iresite.org)
- Teratoma in an Adolescent with Malignant Transformation into Embryonal Rhabdomyosarcoma
- Rhabdomyosarcoma: Molecular diagnostics of patients classified by morphology and immunohistochemistry with emphasis on bone marrow and purged peripheral blood progenitor cells involvement
- Nádory ze skupiny Ewingova sarkomu - molekulární biologie a genetika
- A girl with neurofibromatosis type 1, atypical autism and mosaic ring chromosome 17
- Prophylactic human granulocyte colony-stimulating factor after induction therapy in pediatric acute myeloid leukemia
- Submicroscopic bone marrow involvement in isolated extramedullary relapses in childhood acute lymphoblastic leukemia: a more precise definition of %22isolated%22 and its possible clinical implications, a collaborative study of the Resistant Disease Committee
- Telomere length in peripheral blood cells of germline TP53 mutation carriers is shorter than that of normal individuals of corresponding age
- DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells
- The identification of (ETV6)/RUNX1-regulated genes in lymphopoiesis using histone deacetylase inhibitors in ETV6/RUNX1-positive lymphoid leukemic cells
- Molecular and immunohistochemical analysis of ER13132 expression in correlation with proliferation rate. in synovial sarcoma
- Standardisation of operating procedures for the detection of minimal disease by QRT-PCR in children with neuroblastoma: Quality assurance on behalf of SIOPEN-R-NET
- Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine
- Childhood secondary ALL after ALL treatment
- Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial
- A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial
- Detectable minimal residual disease before allogeneic hematopoietic stem cell transplantation predicts extremely poor prognosis in children with acute lymphoblastic leukemia
- Disappearance of pre-existing high HHV-6 DNA load in blood after allogeneic SCT
- Failure of multiple antivirals to affect high HHV-6 DNAaemia resulting from viral chromosomal integration in case of severe aplastic anaemia
- Correlation of DNA ploidy with location and type of melanoma in dogs
- Metallothioneins and cancer
- Expression of glutamate carboxypeptidase II in human brain
- CNS Irradiation in Pediatric Acute Myleoid Leukemia: Equal Results by 12 or 18 Gy in Studies AML-BFM98 and 2004
- Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia
- Mechanisms of ellipticine-mediated resistance in UKF-NB-4 neuroblastoma cells
- Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria
- Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome
- The comparison of cytotoxicity of the anticancer drugs doxorubicin and ellipticine to human neuroblastoma cells
- Genetické změny high-risk neuroblastomové buněčné linie vyvolané kultivací s ellipticinem
- Getting the numbers straight in pediatric MDS: Distribution of subtypes after exclusion of Down syndrome
- Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia
- Reolysin(R) - Oncolytic virus
- WT1 protein expression in childhood acute leukemia
- WT1 protein expression in slowly proliferating myeloid leukemic cell lines is scarce throughout the cell cycle with a minimum in G(0)/G(1) phase
- Třetí celostátní protokol léčby dětské akutní lymfoblastické leukemie znamenal další zlepšení výsledků. Studie ALL-BFM 95 u dětí v České republice 1995-2002
- Druhá celostátní léčebná studie AML-BFM 98 zvýšila úspěšnost v dosažení remise a zlepšila celkové přežití dětí s akutní myeloidní leukemií v České republice
- Covert preleukemia driven by MLL gene fusion
- Signature profiles of CMV-specific T-cells in patients with CMV reactivation after hematopoietic SCT
- TEL/AML1-Positive Patients Lacking TEL Exon 5 Resemble Canonical TEL/AML1 Cases
- Detection and monitoring of normal and leukemic cell populations with hierarchical clustering of flow cytometry data
- EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols
- Skin Lesions in a Boy With X-linked Lymphoproliferative Disorder: Comparison of 5 SH2D1A Deletion Cases
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