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| Description
| - A number of current therapeutic drugs, as well as new substances being developed, affect the two main systems involved in the defence ot the living organisms. Both the nervous and immune systems, despite their autonomy, closaly cooperate, and a disease of one system very often causes disorders in the other system. The aim of the project is to better understand the relationship between these two systems and the possibilities for their pharmacological treatment. The other goal is to study the mechanism underlying the effect of therapeutic drugs and foreign substances on molecular and receptor levels and their genotoxic effects, for more rational use of the pharmacotherapeutical effects of these substances in clinical practice. Finally, the attention will be devoted a) to the effect of drugs on the striking power of the organism, b) the development of drugs with the influence on metabotropic glutamate receptors, c) the examination of enzymatic inhibitors with the aim to improve healing. (en)
- Řada stávajících farmak, ale i nově vyvíjených látek, působí na oba hlavní systémy, hrající klíčovou úlohu v obraně organismu. Oba systémy, tj. centrální nervový a imunitní, přes určitou autonomii spolu vzájemně úzce komunikují a onemocnění jednoho systému způsobuje často i poruchy v systému druhém. Cílem projektu je blíže porozumět vzájemné závislosti obou těchto systémů a možnosti jejich farmakologického ovlivnění. Dalším cílem je studium mechanismu účinku farmak a cizorodých látek na molekulární a receptorové úrovni a jejich genotoxických účinků za účelem racionálnějšího využití farmakoterapeutických účinků těchto látek v klinické praxi. Konečně pozornost bude věnována a) vlivu farmak na aktivitu faktorů, které mají klíčový význam v obranyschopnosti organizmu, b) vývoji nových léčiv působících na metabotropní glutamátové receptory a c) vyšetření vhodných enzymatických inhibitorů s cílem zlepšit hojivé procesy.
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| Title
| - Revealing the mechanism underlying the effect of therapeutic drugs modulating the activity of the immune and nervous systems in order to find new types of substances for clinical practice (en)
- Objasnění mechanismu účinku farmak modulujících činnost imunitního a nervového systému s cílem nalézt nové typy látek pro klinickou praxi
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ez/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...vavai/cez/dodavka
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| http://linked.open...ez/duvernostUdaju
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| http://linked.open...in/vavai/cez/faze
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| http://linked.open...ai/cez/hlavniObor
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| http://linked.open...vai/cez/hodnoceni
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| http://linked.open.../cez/kategorieVaV
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| http://linked.open.../cez/klicovaSlova
| - immunomodulators;immune system;central nervous system;structure-function relationship;wounds healing (en)
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| http://linked.open...icUkonceniPodpory
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| http://linked.open...icZahajeniPodpory
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| http://linked.open...cez/partnerHlavni
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| http://linked.open...z/poceVysledkuRIV
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cez/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open.../vavai/cez/resort
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| http://linked.open...okUkonceniPodpory
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| http://linked.open...okZahajeniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open.../cez/vedlejsiObor
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| http://linked.open...n/vavai/cez/zamer
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| http://linked.open...sledkuDodavatelem
| - Immunomodulatory activity of acyclic nucleoside phosphonates was revealed. New allosteric modulators bind in each subunit of metabotropic glutamate receptor. Inhibitors of activated serine and membrane proteases enable healing processes. (en)
- Virostatika z acyklických nukleosidfosfonátů mají imunostimulační vlastnosti. Nové alosterické modulátory se váží do každé podjednotky metabotropních glutamátových receptorů. Inhibitory aktivovaných serinových a membránových proteáz zlepšují hojení. (cs)
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| http://linked.open...cez/zivotniCyklus
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| is http://linked.open...n/vavai/riv/zamer
of | - High-resolution magic angle spinning (1)H NMR spectroscopy of metabolic changes in rabbit lens after treatment with dexamethasone combined with UVB exposure
- Involvement of adenosine A1 receptors in upregulation of nitric oxide by acyclic nucleotide analogues
- Surprises and omissions in toxicology
- Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice.
- Age-related changes in superoxide dismutase, glutathione peroxidase, catalase and xanthine oxidoreductase/xanthine oxidase activities in the rabbit cornea
- Evaluation of a flat membrane hepatocyte bioreactor for pharmacotoxicological applications: evidence that inhibition of spontaneously produced nitric oxide improves cell functionality
- Dipeptidyl peptidase IV (DPPIV) activity in the tear fluid as an indicator of the severity of corneal injury: a histochemical and biochemical study
- Irradiation of the rabbit cornea with UVB rays stimulates the expression of nitric oxide synthases-generated nitric oxide and the formation of cytotoxic nitrogen-related oxidants
- High resolution MAS 1H NMR spectroscopic analysis of rabbit cornea after treatment with dexamethasone and exposure to UVB radiation
- Effect of UVA and UVB irradiation on the metabolic profile of rabbit cornea and lens analysed by HR-MAS H NMR spectroscopy.
- Nitric oxide metabolites in gnotobiotic piglets orally infected with Salmonella enterica serovar Typhimurium.
- Neutronová záchytová terapie-zahájení klinických zkoušek.
- Antiviral acyclic nucleoside phosphonates: A novel group of immunomodulatroy agents.
- Activation by 9-( R )-[2-(phosphonomethoxy)propyl]adenine of chemokine (RANTES, macrophage inflammatory protein 1.alfa.) and cytokine (tumor necrosis factor alpha, interleukin-10 [IL-10], IL-1.beta.) production.
- Adamantylamide dipeptide stimulates hematopoiesis in mice exposed to sublethal doses of ionizing radiation and increases survival in lethally irradiated animals.
- Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes.
- Haemopoietic stimulation and radioprotective effects of the immunomodulator adamantylamide dipeptide.
- The Intracellular Loops of the GB2 Subunit Are Crucial for G-Protein Coupling of the Heteromeric γ-Aminobutyrate B Receptor.
- Activation of macrophages by food antigens:enhancing effect of gluten on nitric oxide and cytokine production.
- Adamantylamide dipeptide stimulates hematopoiesis and increases survival in irradiated mice.
- UV rays, the Prooxidant/Antioxidant Imbalance in the Cornea and Oxidativa Eye Damage
- UV Rays, the prooxidant/antioxidant imbalance in the cornea and oxidative eye damage
- Hemopoiesis-stimulating action of adamantylamide dipeptide: kinetics of increase of GM-CFC in femur and co-stimulating activity of serum, role of bone marrow stromal cells.
- Immunobiological activity of N -/2-(phosphonomethoxy)alkyl/ derivatives of N6 -substituted adenines, and 2,6-diaminopurines
- Comparative histochemical and immunohistochemical study on xanthine oxidoreductase/xanthine oxidase in mammalian corneal epithelium
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| is http://linked.open...omain/vavai/zamer
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| is http://linked.open...n/vavai/cez/zamer
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