About: Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes.

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About: Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethal gamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time window (72h before and 48h after irradiation). L-AdDP significantly increased non-specific immunity against Candida albicans infectious model. L-AdDP could be therapeutically beneficial to moderate the haemopoietic damage and induce non-specific immunity to support the antimicrobial treatment of immunocompromised patients.Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethal gamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time window (72h before Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethal gamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time window (72h before and 48h after irradiation). L-AdDP significantly increased non-specific immunity against Candida albicans infectious model. L-AdDP could be therapeutically beneficial to moderate the haemopoietic damage and induce non-specific immunity to support the antimicrobial treatment of immunocompromised patients.Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethal gamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time window (72h before (en)
Title	Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes. Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes. (en)
skos:prefLabel	Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes. Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes. (en)
skos:notation	RIV/68081707:_____/01:17013050!RIV/2003/AV0/A17003/N
http://linked.open.../vavai/riv/strany	167;175
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(PZ-Z2/25), Z(AV0Z5004920), Z(AV0Z5008914)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Vacek, Antonín
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	697263
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/01:17013050
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	liposomes; muramyl dipeptide analogues; radioprotective (en)
http://linked.open.../riv/klicoveSlovo	radioprotective liposomes muramyl dipeptide analogues
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[51692C1BFE86]
http://linked.open...i/riv/nazevZdroje	International Immunopharmacology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Imunotherapeutics for treatment and prevention of serious diseases.
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Mašek, Karel Turánek, J. Bláha, L. Vacek, Antonín Záluská, D. Borkovcová, P. Thurnvaldová, J.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors Revealing the mechanism underlying the effect of therapeutic drugs modulating the activity of the immune and nervous systems in order to find new types of substances for clinical practice
issn	1567-5769
number of pages	9 (xsd:int)

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