About: Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Improved detection methods for diagnosis of malignant mesothelioma (MM) are essential for detection and treatment. miRNAs isolated from fresh-frozen biopsies of MM patients were tested for the expression of 88 types of miRNA involved in cancerogenesis. Three significantly downregulated miRNAs were assayed in cancerous tissue and adjacent non-cancerous tissue sample pairs collected from 27 formalin-fixed, paraffin-embedded MM tissues by quantitative RT-PCR. Only miR-126 remained downregulated in the malignant tissues. The performance of the selected miR-126 as biomarker was evaluated in serum samples of asbestos-exposed subjects and MM patients and compared with controls. MiR-126 was not affected by asbestos exposure, whereas it was found associated with VEGF serum levels. Levels of miR-126 in serum, and its levels in patients' serum in association with a specific marker of MM, SMRPs, correlate with subjects at high risk to develop MM. Improved detection methods for diagnosis of malignant mesothelioma (MM) are essential for detection and treatment. miRNAs isolated from fresh-frozen biopsies of MM patients were tested for the expression of 88 types of miRNA involved in cancerogenesis. Three significantly downregulated miRNAs were assayed in cancerous tissue and adjacent non-cancerous tissue sample pairs collected from 27 formalin-fixed, paraffin-embedded MM tissues by quantitative RT-PCR. Only miR-126 remained downregulated in the malignant tissues. The performance of the selected miR-126 as biomarker was evaluated in serum samples of asbestos-exposed subjects and MM patients and compared with controls. MiR-126 was not affected by asbestos exposure, whereas it was found associated with VEGF serum levels. Levels of miR-126 in serum, and its levels in patients' serum in association with a specific marker of MM, SMRPs, correlate with subjects at high risk to develop MM. (en)
Title	Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma (en)
skos:prefLabel	Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma (en)
skos:notation	RIV/86652036:_____/11:00369516!RIV12-AV0-86652036
http://linked.open...avai/predkladatel	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/08/0811), Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Neužil, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	187336
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/11:00369516
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Malignant pleural mesothelioma; microRNAs; soluble mesothelin-related peptides (en)
http://linked.open.../riv/klicoveSlovo	Malignant pleural mesothelioma microRNAs soluble mesothelin-related peptides
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[06D3895CF5B3]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	16 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanism of ROS generation and mitochondrial permeabilization
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Amati, M. Bracci, M. Carbonari, D. Emanuelli, M. Gasparini, S. Mazzanti, P. Neužil, Jiří Pignotti, E. Pozzi, V. Ranaldi, R. Sabbatini, A. Santarelli, L. Sartini, D. Staffolani, S. Strafella, E. Tomasetti, M.
http://linked.open...ain/vavai/riv/wos	000289058300007
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	1932-6203
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0018232
is http://linked.open...avai/riv/vysledek of	Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma

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