About: The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Psychiatric diseases are associated with elevated levels of pro-inflammatory cytokines in affected patients. Cytokines IL-1 and TNF- enhance the production of serotonin transporter (5-HT) thus, antidepressants could mediate their effect by downregulation of these cytokines. Therefore, we studied the influence of ketamine in male Wistar/Hann rats on IL-1 and TNF- and 5-HT activity in the blood and brain. Both cytokines increased up to 140% and 150% only in control animals, not in the ketamine group. Ketamine administration led to lower 5-HT levels in the hippocampus compared to controls (t=2.218, p<0.05). The hippocampal 5-HT levels correlated negatively with the basal TNF- and positively with the absolute and relative change of this cytokine in the whole sample, which suggests inhibition of IL-1 and TNF-activity. The mechanisms responsible for the interaction between the pro-inflammatory pathway, 5-HT and antidepressant effect of ketamine remain unknown Psychiatric diseases are associated with elevated levels of pro-inflammatory cytokines in affected patients. Cytokines IL-1 and TNF- enhance the production of serotonin transporter (5-HT) thus, antidepressants could mediate their effect by downregulation of these cytokines. Therefore, we studied the influence of ketamine in male Wistar/Hann rats on IL-1 and TNF- and 5-HT activity in the blood and brain. Both cytokines increased up to 140% and 150% only in control animals, not in the ketamine group. Ketamine administration led to lower 5-HT levels in the hippocampus compared to controls (t=2.218, p<0.05). The hippocampal 5-HT levels correlated negatively with the basal TNF- and positively with the absolute and relative change of this cytokine in the whole sample, which suggests inhibition of IL-1 and TNF-activity. The mechanisms responsible for the interaction between the pro-inflammatory pathway, 5-HT and antidepressant effect of ketamine remain unknown (en)
Title	The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply (en)
skos:prefLabel	The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply (en)
skos:notation	RIV/86652036:_____/11:00369317!RIV12-AV0-86652036
http://linked.open...avai/predkladatel	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(1M0517), S, Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Růžičková, Šárka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	204318
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/11:00369317
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	serotonin; proinflammatory; cytokines (en)
http://linked.open.../riv/klicoveSlovo	proinflammatory serotonin cytokines
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9BEDC0EAF040]
http://linked.open...i/riv/nazevZdroje	Psychological Medicine
http://linked.open...in/vavai/riv/obor	AN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Horáček, J. Bubeniková-Valešová, V. Höschl, C. Novák, T. Páleníček, T. Rambousek, L. Růžičková, Šárka Tejkalová, H. Vaculín, Š.
http://linked.open...ain/vavai/riv/wos	000292704400022
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	0033-2917
number of pages	3 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply

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