About: Mitochondrially targeted anti-cancer agents

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently,a considerable challenge.Mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans,have been a recent focus of research.Of these compounds, many are hydrophobic agents that associate with various subcellular organelles.Modification of such structures with mitochondria-targeting moieties,for example tagging them with lipophilic cations,would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. We propose that mitochondrial targeting, in particular where the agent associates directly with the target,results in more specific and efficient anti-cancer drugs of potential high clinical relevance Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently,a considerable challenge.Mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans,have been a recent focus of research.Of these compounds, many are hydrophobic agents that associate with various subcellular organelles.Modification of such structures with mitochondria-targeting moieties,for example tagging them with lipophilic cations,would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. We propose that mitochondrial targeting, in particular where the agent associates directly with the target,results in more specific and efficient anti-cancer drugs of potential high clinical relevance (en)
Title	Mitochondrially targeted anti-cancer agents Mitochondrially targeted anti-cancer agents (en)
skos:prefLabel	Mitochondrially targeted anti-cancer agents Mitochondrially targeted anti-cancer agents (en)
skos:notation	RIV/86652036:_____/10:00361635!RIV12-AV0-86652036
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Neužil, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	271609
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/10:00361635
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Mitochondrial targeting; pro-oxidant effect; reactive oxygen species (en)
http://linked.open.../riv/klicoveSlovo	Mitochondrial targeting reactive oxygen species pro-oxidant effect
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[838DAD08BCB6]
http://linked.open...i/riv/nazevZdroje	Mitochondrion
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Neužil, Jiří Biasutto, L. Dong, L. A. Zoratti, M.
http://linked.open...ain/vavai/riv/wos	000284660000011
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	1567-7249
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mito.2010.06.004
is http://linked.open...avai/riv/vysledek of	Mitochondrially targeted anti-cancer agents Mitochondrially targeted anti-cancer agents

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