About: Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells

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About: Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We used the proliferation test (E-screen assay) in MCF-7 breast cancer cells and reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis of TFF1 gene expression to analyze estrogenicity of the studied compounds. RT-qPCR has proven to be a fast and valuable molecular technique in gene expression quantification. HBCD but not TBBPA increased cell proliferation in MCF-7 cells and up-regulates TFF1 gene expression in a concentration-dependent manner. Anti-estrogen ICI 182,780 inhibits up-regulation of TFF1 by HBCD. We showed that HBCD displays estrogen-like effects on MCF-7 cells. TBBPA, on the other hand, has not shown any estrogenic effect mediated by the estrogen receptor alpha. We used the proliferation test (E-screen assay) in MCF-7 breast cancer cells and reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis of TFF1 gene expression to analyze estrogenicity of the studied compounds. RT-qPCR has proven to be a fast and valuable molecular technique in gene expression quantification. HBCD but not TBBPA increased cell proliferation in MCF-7 cells and up-regulates TFF1 gene expression in a concentration-dependent manner. Anti-estrogen ICI 182,780 inhibits up-regulation of TFF1 by HBCD. We showed that HBCD displays estrogen-like effects on MCF-7 cells. TBBPA, on the other hand, has not shown any estrogenic effect mediated by the estrogen receptor alpha. (en)
Title	Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells (en)
skos:prefLabel	Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells (en)
skos:notation	RIV/86652036:_____/10:00356209!RIV12-AV0-86652036
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M06011), P(2B06151), Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pěknicová, Jana Elzeinová, Fatima Děd, Lukáš Dorosh, Andriy
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	247878
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/10:00356209
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	endocrine disruptors; BRF - brominated flame retardant; MCF-7 cells; TFF1 - trefoil factor (en)
http://linked.open.../riv/klicoveSlovo	BRF - brominated flame retardant MCF-7 cells TFF1 - trefoil factor endocrine disruptors
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[1738C0BF7599]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biodegradation of polybrominated compounds, monitoring of concentration changes of pollutants and their intermediates in the environment The Centre of Molecular Methods for Monitoring the Diffuse Pollution of the Environment.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Elzeinová, Fatima Pěknicová, Jana Děd, Lukáš Dorosh, Andryi
http://linked.open...ain/vavai/riv/wos	000288623700007
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	0015-5500
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells

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