About: The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups. The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups. (en)
Title	The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice (en)
skos:prefLabel	The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice (en)
skos:notation	RIV/86652036:_____/09:00349100!RIV11-MSM-86652036
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M06011), P(2B06151), Z(AV0Z50390703), Z(AV0Z50520701)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pěknicová, Jana Elzeinová, Fatima Nováková, Vendula Kubátová, Alena
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	312157
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/09:00349100
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	vinclozolin; spermatozoa; anti-androgen (en)
http://linked.open.../riv/klicoveSlovo	spermatozoa anti-androgen vinclozolin
http://linked.open...ontrolniKodProRIV	[70E76461AF08]
http://linked.open...v/mistoKonaniAkce	Barcelona
http://linked.open...i/riv/mistoVydani	Barcelona
http://linked.open...i/riv/nazevZdroje	Journal of Andrology - 9th International Congress of Andrology
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Biodegradation of polybrominated compounds, monitoring of concentration changes of pollutants and their intermediates in the environment The Centre of Molecular Methods for Monitoring the Diffuse Pollution of the Environment.
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Elzeinová, Fatima Pěknicová, Jana Nováková, Vendula Kubátová, Alena Buckiová, Daniela
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open...ain/vavai/riv/wos	000263849500133
http://linked.open.../riv/zahajeniAkce	2009-03-07 (xsd:date)
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Establishing of the Biotechnology Institute ASCR
issn	0196-3635
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	The American Society
is http://linked.open...avai/riv/vysledek of	The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 82 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software