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| rdf:type
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| Description
| - Byla studována úloha proteinu Daxx v modulaci apoptózy indukované v kardiomyocytech oxidativním stresem. Vystavení buněk podobných kardiomyocytům oxidativnímu stresu nebo simulované hypoxii zvýšilo hladinu akumulovaných ROS a apoptózu. Za podmínek subapoptotické stimulace kardiomyocytů nebyl pozorován žádný vzestup hladiny Daxx proteinu, ale změnila se jeho lokalizace z jádra do cytoplasmy. Nadexprese Daxxu chránila buňky před apoptózou, zatímco jejich citlivost k buněčné smrti byla zvýšena snížením exprese Daxxu pomocí siRNA. Snížení hladiny Daxx proteinu zcitlivělo kardiomyocyty ke spontánní apoptóze, což svědčí pro to, že tento protein může mít za fyziologických podmínek roli příznivou pro přežívání. Konečně bylo ukázáno, že DJ-1, protein zřejmě vyčleňující Daxx v jádře za podmínek oxidativního stresu a zabraňující tak jeho cytosolické translokaci, byl lokalizován pouze v cytoplasmě kardiomyocytů (cs)
- The role of the death-associated protein Daxx in modulation of apoptosis induced in cardiac myocytes by oxidative stress was studied. Exposure of cardiomyocyte-like cells to oxidative stress or simulated hypoxia increased the level of accumulated ROS and apoptosis. Under conditions of sub-apoptotic stimulation of cardiac myocytes, there was no increase in the level of the Daxx protein, but it translocated from the nucleus to the cytoplasm. Daxx overexpression protected the cells from apoptosis, while they were sensitised to cell death following its down-regulation by siRNA. Lowering the level of the Daxx protein sensitised cardiac myocytes to spontaneous apoptosis, suggesting that the protein may also have a prosurvival role under physiological conditions. Finally, it was shown that DJ-1, a protein suggested previously to sequester Daxx in the nucleus under conditions of oxidative stress preventing thus its cytosolic translocation, was localised in the cytoplasm of cardiac myocytes
- The role of the death-associated protein Daxx in modulation of apoptosis induced in cardiac myocytes by oxidative stress was studied. Exposure of cardiomyocyte-like cells to oxidative stress or simulated hypoxia increased the level of accumulated ROS and apoptosis. Under conditions of sub-apoptotic stimulation of cardiac myocytes, there was no increase in the level of the Daxx protein, but it translocated from the nucleus to the cytoplasm. Daxx overexpression protected the cells from apoptosis, while they were sensitised to cell death following its down-regulation by siRNA. Lowering the level of the Daxx protein sensitised cardiac myocytes to spontaneous apoptosis, suggesting that the protein may also have a prosurvival role under physiological conditions. Finally, it was shown that DJ-1, a protein suggested previously to sequester Daxx in the nucleus under conditions of oxidative stress preventing thus its cytosolic translocation, was localised in the cytoplasm of cardiac myocytes (en)
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| Title
| - Daxx inhibits stress-induced apoptosis in cardiac myocytes
- Daxx inhibuje apoptózu indukovanou stresem v kardiomyocytech (cs)
- Daxx inhibits stress-induced apoptosis in cardiac myocytes (en)
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| skos:prefLabel
| - Daxx inhibits stress-induced apoptosis in cardiac myocytes
- Daxx inhibuje apoptózu indukovanou stresem v kardiomyocytech (cs)
- Daxx inhibits stress-induced apoptosis in cardiac myocytes (en)
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| skos:notation
| - RIV/86652036:_____/08:00325125!RIV09-AV0-86652036
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA305/07/1008), Z(AV0Z50520701)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/86652036:_____/08:00325125
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Daxx; apoptosis; oxidative stress (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Neužil, Jiří
- Dong, L. F.
- Zobalová, Renata
- Chladová, Jaromíra
- Swettenham, E.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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