About: Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption

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About: Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It is demonstrated that a good biomimetic model lipid membrane with dynamic fluidity can be established on optically transparent nanocrystalline diamond (OTND) with surface roughness below 10nm. Maigainin II, an antimicrobial peptide, is chosen to investigate the permeation of artificial bacterial membranes constructed on OTND. Due to the unique combination of optical transparency and highly sensitive surface conducting channel, intrinsic OTND affords the possibility of dual-mode sensing based on optical and field effect properties. This opens up new possibilities for making integrated biomolecule–semiconductor microdevices, or sensors where the binding of biomolecules can be tracked using confocal microscopy whilst the associated changes in charge density during membrane perforation can be tracked using the space charge effect in the semiconductor. It is demonstrated that a good biomimetic model lipid membrane with dynamic fluidity can be established on optically transparent nanocrystalline diamond (OTND) with surface roughness below 10nm. Maigainin II, an antimicrobial peptide, is chosen to investigate the permeation of artificial bacterial membranes constructed on OTND. Due to the unique combination of optical transparency and highly sensitive surface conducting channel, intrinsic OTND affords the possibility of dual-mode sensing based on optical and field effect properties. This opens up new possibilities for making integrated biomolecule–semiconductor microdevices, or sensors where the binding of biomolecules can be tracked using confocal microscopy whilst the associated changes in charge density during membrane perforation can be tracked using the space charge effect in the semiconductor. (en)
Title	Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption (en)
skos:prefLabel	Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption (en)
skos:notation	RIV/68378271:_____/09:00328844!RIV10-AV0-68378271
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z10100520)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Nesládek, Miloš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	344740
http://linked.open...ai/riv/idVysledku	RIV/68378271:_____/09:00328844
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nanocrystalline diamond; biocompatibility; supported lipid bilayers; biosensors; solution gate field effect transistor (en)
http://linked.open.../riv/klicoveSlovo	supported lipid bilayers biocompatibility biosensors solution gate field effect transistor nanocrystalline diamond
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[7F6AB4E6F1CD]
http://linked.open...i/riv/nazevZdroje	Advanced Functional Materials
http://linked.open...in/vavai/riv/obor	BM
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Nesládek, Miloš Loh, K. P. Van Hove, E. Ang, P. K. Wohland, T.
http://linked.open...ain/vavai/riv/wos	000262584800010
http://linked.open...n/vavai/riv/zamer	Specific effects in condensed systems with reduced dimension and broken symmetry
issn	1616-301X
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption

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