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| rdf:type
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| Description
| - Recovery from CL is usually accompanied with long-lasting protection and induction of strong immune response. The phenotypes, generation and maintenance of central (=T-CM) and effector (=T-EM) memory T cell subsets in human leishmaniasis are not well known. Profile of T cell subsets were analyzed on peripheral CD8(+) T cells from volunteers with history of cutaneous leishmaniasis (HCL). In HCL and control groups, mean frequencies of CCR7(+)CD45RA(+)CD8(+) naive and CCR7(-)CD45RA(-)CD8(+) T-EM cells were higher than other subsets before culture, but after stimulation with soluble Leishmania antigen, the frequency of naive T cells was significantly decreased and the frequency of T-EM cells was significantly increased. T-EM phenotype composed the highest portion of proliferating Carboxy Fluorescein diacetate Succinimidyl Ester (CFSE)-dim population which was significantly higher in HCL volunteers than in control group. Stimulation of isolated CD8(+) memory T cells, but not naive T cells, from HCL volunteers induced a significantly higher IFN-gamma production compared with that of healthy controls. Intracellular IFN-gamma staining provided the same result. Memory population is shown to be responsible for Leishniania-induced IFN-gamma production. Leishmania-reactive proliferating T-EM cells were identified as the most frequent subset which may play a role in recall immune response and protection against Leishmania infection.
- Recovery from CL is usually accompanied with long-lasting protection and induction of strong immune response. The phenotypes, generation and maintenance of central (=T-CM) and effector (=T-EM) memory T cell subsets in human leishmaniasis are not well known. Profile of T cell subsets were analyzed on peripheral CD8(+) T cells from volunteers with history of cutaneous leishmaniasis (HCL). In HCL and control groups, mean frequencies of CCR7(+)CD45RA(+)CD8(+) naive and CCR7(-)CD45RA(-)CD8(+) T-EM cells were higher than other subsets before culture, but after stimulation with soluble Leishmania antigen, the frequency of naive T cells was significantly decreased and the frequency of T-EM cells was significantly increased. T-EM phenotype composed the highest portion of proliferating Carboxy Fluorescein diacetate Succinimidyl Ester (CFSE)-dim population which was significantly higher in HCL volunteers than in control group. Stimulation of isolated CD8(+) memory T cells, but not naive T cells, from HCL volunteers induced a significantly higher IFN-gamma production compared with that of healthy controls. Intracellular IFN-gamma staining provided the same result. Memory population is shown to be responsible for Leishniania-induced IFN-gamma production. Leishmania-reactive proliferating T-EM cells were identified as the most frequent subset which may play a role in recall immune response and protection against Leishmania infection. (en)
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| Title
| - Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis
- Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis (en)
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| skos:prefLabel
| - Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis
- Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis (en)
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| skos:notation
| - RIV/68378050:_____/12:00389981!RIV13-AV0-68378050
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/12:00389981
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - CD8(+) T cells; memory T cells; cutaneous leishmaniasis; IFN-gamma (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Tasbihi, M.
- Sohrabi, Yahya
- Eskandari, S. E.
- Khamesipour, A.
- Mohammadi, A. M.
- Rostami, M. N.
- Sarrafnejad, A.
- Shahrestani, T.
- Valian, H. K.
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| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1016/j.micinf.2012.02.006
|
| is http://linked.open...avai/riv/vysledek
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