About: Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A

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About: Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The avian sarcoma and leukosis virus (ASLV) family of retroviruses evolved from a common ancestor enters the host cell through several types of specific surface receptors. Rare genetic defects of these receptors determining the resistance of cells to ASLV members have been sought in a panel of inbred chicken lines. Mutations with mild effect on virus entry, i.e. semiresistance-causing mutations, point to the structural moieties necessary for the virus-receptor binding and subsequent fusion of retrovirus and host cell membranes. We identified intronic deletions of splicing signals within the gene encoding the Tva receptor behind the semiresitance of inbread chickens to the A subgroup of ASLV. Similar mutations exist in the homologous human low density lipoprotein (LDL) receptor in hypercholesterolaemia patients. We also higlight the finding of these mutations in red jungle fowls. It must be a common type of polymorphism mainatined by the selection pressure of an infectious retrovirus. The avian sarcoma and leukosis virus (ASLV) family of retroviruses evolved from a common ancestor enters the host cell through several types of specific surface receptors. Rare genetic defects of these receptors determining the resistance of cells to ASLV members have been sought in a panel of inbred chicken lines. Mutations with mild effect on virus entry, i.e. semiresistance-causing mutations, point to the structural moieties necessary for the virus-receptor binding and subsequent fusion of retrovirus and host cell membranes. We identified intronic deletions of splicing signals within the gene encoding the Tva receptor behind the semiresitance of inbread chickens to the A subgroup of ASLV. Similar mutations exist in the homologous human low density lipoprotein (LDL) receptor in hypercholesterolaemia patients. We also higlight the finding of these mutations in red jungle fowls. It must be a common type of polymorphism mainatined by the selection pressure of an infectious retrovirus. (en)
Title	Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A (en)
skos:prefLabel	Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A (en)
skos:notation	RIV/68378050:_____/12:00374805!RIV12-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP502/10/1651), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hejnar, Jiří Trejbalová, Kateřina Kučerová, Dana Plachý, Jiří Svoboda, Jan Reinišová, Markéta Geryk, Josef Šenigl, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	142807
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/12:00374805
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	avian sarcoma and leukosis virus; virus-host coevolution; resistance to retroviruses (en)
http://linked.open.../riv/klicoveSlovo	avian sarcoma and leukosis virus resistance to retroviruses virus-host coevolution
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6F43F26A35CC]
http://linked.open...i/riv/nazevZdroje	Journal of Virology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Characterization of new avian sarcoma and leukosis virus (ASLV) receptor alleles as revealed by the analysis of semi-resistant cells
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	86
http://linked.open...iv/tvurceVysledku	Plachý, Jiří Svoboda, Jan Hejnar, Jiří Kučerová, Dana Trejbalová, Kateřina Geryk, Josef Reinišová, Markéta Šenigl, Filip
http://linked.open...ain/vavai/riv/wos	000299862500012
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1098-5514
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1128/JVI.05771-11
is http://linked.open...avai/riv/vysledek of	Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A

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