About: Chicken models of retroviral insertional mutagenesis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The introductory part summarizes published results of searching for cancer-related genes obtained using chicken models of insertional mutagenesis and presents new views of mechanisms by which integrated proviruses deregulate host gene expression. The major part of the chapter is devoted to the most advanced model based on MAV-2 retrovirus that has been elaborated recently by the authors. So far the model allowed identification of genes participating in the formation of nephroblastomas, lung and liver hemangiosarcomas, liver carcinomas and cholangiocarcinomas. Most of these tumor types were induced with the help of the new phenomenon discovered recently by the authors: non-tumor cells released into the blood circulation and passing further into tissues strongly promote the formation of a tumor from latent malignant cells primed by MAV-2 insertional mutagenesis. The data described in the chapter are up-to-date and include the newest results of the authors that has not been published yet. The chapter shows that chicken model of cancerogenesis is the prolific one, can advantageously complement mammalian models and contribute to our knowledge of genes, pathways and networks implicated in cancerogenesis leading to data that could translate to human medicine. The introductory part summarizes published results of searching for cancer-related genes obtained using chicken models of insertional mutagenesis and presents new views of mechanisms by which integrated proviruses deregulate host gene expression. The major part of the chapter is devoted to the most advanced model based on MAV-2 retrovirus that has been elaborated recently by the authors. So far the model allowed identification of genes participating in the formation of nephroblastomas, lung and liver hemangiosarcomas, liver carcinomas and cholangiocarcinomas. Most of these tumor types were induced with the help of the new phenomenon discovered recently by the authors: non-tumor cells released into the blood circulation and passing further into tissues strongly promote the formation of a tumor from latent malignant cells primed by MAV-2 insertional mutagenesis. The data described in the chapter are up-to-date and include the newest results of the authors that has not been published yet. The chapter shows that chicken model of cancerogenesis is the prolific one, can advantageously complement mammalian models and contribute to our knowledge of genes, pathways and networks implicated in cancerogenesis leading to data that could translate to human medicine. (en)
Title	Chicken models of retroviral insertional mutagenesis Chicken models of retroviral insertional mutagenesis (en)
skos:prefLabel	Chicken models of retroviral insertional mutagenesis Chicken models of retroviral insertional mutagenesis (en)
skos:notation	RIV/68378050:_____/11:00378894!RIV13-GA0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/09/1727), Z(AV0Z50520514)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Dvořák, Michal Pečenka, Vladimír Karafiát, Vít
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	190176
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00378894
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	insertional mutagenesis; chicken model; MAV retroviruses (en)
http://linked.open.../riv/klicoveSlovo	MAV retroviruses chicken model insertional mutagenesis
http://linked.open...ontrolniKodProRIV	[29EB32943B13]
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...i/riv/nazevZdroje	Insertional Mutagenesis Strategies in Cancer Genetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...v/pocetStranKnihy	200 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Large-scale identification of genes responsible for the formation of solid tumours
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Dvořák, Michal Karafiát, Vít Pečenka, Vladimír
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
number of pages	36 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/978-1-4419-7656-7
http://purl.org/ne...btex#hasPublisher	Springer-Verlag
https://schema.org/isbn	978-1-4419-7655-0
is http://linked.open...avai/riv/vysledek of	Chicken models of retroviral insertional mutagenesis

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