About: Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We evaluated the anti-tumour effects of the DNA methyltransferase inhibitor 5-azacytidine (5AC) The 5AC therapy was combined with immunotherapy, using a murine model for HPV16-associated tumours. We have demonstrated 5AC additive effects against MHC class I-positive and -deficient tumours when combined with unmethylated CpG oligodeoxynucleotides (CpG ODN) or with IL-12-producing cellular vaccine. The efficacy of the combined chemoimmunotherapy against originally MHC class I-deficient tumours was partially dependent on the CD8+-mediated immune responses. Increased cell surface expression of MHC class I cell molecules, associated with upregulation of the antigen-presenting machinery-related genes, as well as of genes encoding selected components of the IFNγ signalling pathway in tumours explanted from 5AC-treated animals, were observed. We evaluated the anti-tumour effects of the DNA methyltransferase inhibitor 5-azacytidine (5AC) The 5AC therapy was combined with immunotherapy, using a murine model for HPV16-associated tumours. We have demonstrated 5AC additive effects against MHC class I-positive and -deficient tumours when combined with unmethylated CpG oligodeoxynucleotides (CpG ODN) or with IL-12-producing cellular vaccine. The efficacy of the combined chemoimmunotherapy against originally MHC class I-deficient tumours was partially dependent on the CD8+-mediated immune responses. Increased cell surface expression of MHC class I cell molecules, associated with upregulation of the antigen-presenting machinery-related genes, as well as of genes encoding selected components of the IFNγ signalling pathway in tumours explanted from 5AC-treated animals, were observed. (en)
Title	Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status (en)
skos:prefLabel	Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status (en)
skos:notation	RIV/68378050:_____/11:00371265!RIV12-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/07/1410), P(GA301/09/1024), P(GAP301/10/2174), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Reiniš, Milan Mikyšková, Romana Šímová, Jana Bieblová, Jana Bubeník, Jan Indrová, Marie Polláková, Veronika Štěpánek, Ivan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	203612
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00371265
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	5-azacytidine; MHC class I downregulation; tumour chemoimmunotherapy (en)
http://linked.open.../riv/klicoveSlovo	5-azacytidine MHC class I downregulation tumour chemoimmunotherapy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1FB020158141]
http://linked.open...i/riv/nazevZdroje	British Journal of Cancer
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunosuppressive cell populations in the course of tumour progression and therapy. Molecular and cellular mechanisms of tumour chemotherapy: immunomodulatory effects Epigenetické mechanismy regulající geny důležité pro presentaci antigenu a protinádorovou imunitu.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Reiniš, Milan Bieblová, Jana Bubeník, Jan Indrová, Marie Mikyšková, Romana Šímová, Jana Polláková, Veronika Štěpánek, Ivan
http://linked.open...ain/vavai/riv/wos	000296794200009
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0007-0920
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/bjc.2011.428
is http://linked.open...avai/riv/vysledek of	Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status

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