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  • There are numerous data suggesting that two key steps in gene expression - transcription and splicing influence each other closely. For a long time it was known that chromatin modifications regulate transcription, but only recently it was shown that chromatin and histone modifications play a significant role in pre-mRNA splicing. Here we summarize interactions between splicing machinery and chromatin and discuss their potential functional significance. We focus mainly on histone acetylation and methylation and potential mechanisms of their role in splicing. It seems that whereas histone acetylation acts mainly by alterating the transcription rate, histone methylation can also influence splicing directly by recruiting various splicing components.
  • There are numerous data suggesting that two key steps in gene expression - transcription and splicing influence each other closely. For a long time it was known that chromatin modifications regulate transcription, but only recently it was shown that chromatin and histone modifications play a significant role in pre-mRNA splicing. Here we summarize interactions between splicing machinery and chromatin and discuss their potential functional significance. We focus mainly on histone acetylation and methylation and potential mechanisms of their role in splicing. It seems that whereas histone acetylation acts mainly by alterating the transcription rate, histone methylation can also influence splicing directly by recruiting various splicing components. (en)
Title
  • Where splicing joins chromatin
  • Where splicing joins chromatin (en)
skos:prefLabel
  • Where splicing joins chromatin
  • Where splicing joins chromatin (en)
skos:notation
  • RIV/68378050:_____/11:00371260!RIV12-AV0-68378050
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GAP305/10/0424), P(KAN200520801), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
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  • 241736
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  • RIV/68378050:_____/11:00371260
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • chromatin; exon; alternative splicing; transcription; snRNP (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [498972DA86AB]
http://linked.open...i/riv/nazevZdroje
  • Nucleus
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  • 2
http://linked.open...iv/tvurceVysledku
  • Hnilicová, Jarmila
  • Staněk, David
http://linked.open...n/vavai/riv/zamer
issn
  • 1949-1034
number of pages
http://bibframe.org/vocab/doi
  • 10.4161/nucl.2.3.15876
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