About: Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning

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About: Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Formation of a dorsoventral axis is a key event in the early development of most animal embryos. It is well established that bone morphogenetic proteins (Bmps) and Wnts are key mediators of dorsoventral patterning in vertebrates. In the cephalochordate amphioxus, genes encoding Bmps and transcription factors downstream of Bmp signaling such as Vent are expressed in patterns reminiscent of those of their vertebrate orthologues. We found that Bmp but not canonical Wnt signaling regulates promoters of genes encoding homeodomain proteins AmphiVent1 and AmphiVent2. Our data indicate high evolutionary conservation of a core Bmp-triggered gene regulatory network for dorsoventral patterning in chordates and suggest that co-option of the canonical Wnt signaling pathway for dorsoventral patterning in vertebrates represents one of the innovations through which an increased morphological complexity of vertebrate embryo is achieved. Formation of a dorsoventral axis is a key event in the early development of most animal embryos. It is well established that bone morphogenetic proteins (Bmps) and Wnts are key mediators of dorsoventral patterning in vertebrates. In the cephalochordate amphioxus, genes encoding Bmps and transcription factors downstream of Bmp signaling such as Vent are expressed in patterns reminiscent of those of their vertebrate orthologues. We found that Bmp but not canonical Wnt signaling regulates promoters of genes encoding homeodomain proteins AmphiVent1 and AmphiVent2. Our data indicate high evolutionary conservation of a core Bmp-triggered gene regulatory network for dorsoventral patterning in chordates and suggest that co-option of the canonical Wnt signaling pathway for dorsoventral patterning in vertebrates represents one of the innovations through which an increased morphological complexity of vertebrate embryo is achieved. (en)
Title	Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning (en)
skos:prefLabel	Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning (en)
skos:notation	RIV/68378050:_____/11:00355826!RIV11-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA500520604), P(IAA500520908), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozmiková, Irina Smolíková, Jana Kozmik, Zbyněk Vlček, Čestmír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	191699
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00355826
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Wnt Bmp; amphioxus; axial patterning (en)
http://linked.open.../riv/klicoveSlovo	Wnt Bmp amphioxus axial patterning
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[130CC2101DEC]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Developmental Genetics of Amphioxus:Insight into Evolutionary Origin of Vertebrates The role of Pax genes in eye evolution
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Kozmik, Zbyněk Kozmiková, Irina Smolíková, Jana Vlček, Čestmír
http://linked.open...ain/vavai/riv/wos	000287036600003
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1932-6203
number of pages	21 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning

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