About: Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	There are numerous concerns over the potential transfer of pathogens between species during clinical xenotransplantation. Porcine xenografts have been previously used to treat patients with severe burns. As pigs are a known source of zoonotic agents, many diseases must be excluded from pigs used for xenotransplantation. Clostridium difficile is a major cause of neonatal enteritis in pigs, with an important feature that pigs can be its asymptomatic carriers. We examined the incidence of C. difficile PCR ribotypes present in healthy donor pigs to determine if pig faeces, and in particular contamination of skin with faeces, is a potential route for the transfer of C. difficile. Animals were found to have human ribotype 017 present in the faecal matter, but no C. difficile was isolated from skin samples taken from the same animals. Also, due to the risk factors associated with C. difficile infection, the antimicrobial susceptibility of the C. difficile isolates has been determined. There are numerous concerns over the potential transfer of pathogens between species during clinical xenotransplantation. Porcine xenografts have been previously used to treat patients with severe burns. As pigs are a known source of zoonotic agents, many diseases must be excluded from pigs used for xenotransplantation. Clostridium difficile is a major cause of neonatal enteritis in pigs, with an important feature that pigs can be its asymptomatic carriers. We examined the incidence of C. difficile PCR ribotypes present in healthy donor pigs to determine if pig faeces, and in particular contamination of skin with faeces, is a potential route for the transfer of C. difficile. Animals were found to have human ribotype 017 present in the faecal matter, but no C. difficile was isolated from skin samples taken from the same animals. Also, due to the risk factors associated with C. difficile infection, the antimicrobial susceptibility of the C. difficile isolates has been determined. (en)
Title	Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts (en)
skos:prefLabel	Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts (en)
skos:notation	RIV/68378050:_____/09:00335551!RIV10-AV0-68378050
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Veselý, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	304220
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00335551
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	C. difficile; hospital acquired infection; xenotransplant; zoonoses (en)
http://linked.open.../riv/klicoveSlovo	zoonoses C. difficile xenotransplant hospital acquired infection
http://linked.open...odStatuVydavatele	SG - Singapurská republika
http://linked.open...ontrolniKodProRIV	[36A076DE01E7]
http://linked.open...i/riv/nazevZdroje	Xenotransplantation
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Veselý, Pavel Crossan, C. Scobie, L. Bakri, M. M. Brown, D. J. Sutherland, A. D.
http://linked.open...ain/vavai/riv/wos	000273007400003
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0908-665X
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

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