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| Description
| - Studovali jsme efekty IL-12 produkujících buněčných vakcín na cytotoxický a proliferační potenciál CD45+ buněk infiltrujících nádory (TIL) na myším modelu pro HPV16 asociované nádory po chemoterapii pomocí CBM-4A (derivát ifosfamidu). Účinkem chemoterapie poklesly populace inflitrujících CD4+ and CD8+ TIL, zvýšily Gr-1+/CD11b+ TIL a nebyly žádné změny v infiltraci CD4+/CD25+ Treg TIL. Byl pozorován pokles v cytotoxickém a proliferačním potenciálu CD45+ TIL. Následná imunoterapie geneticky modifikovanými nádorovými buňkami TC-1 produkujícími IL-12 zvýšila množství CD8+ a CD4+ buněk infiltrujících nádor, snížila množství Gr-1+/CD11b+ buněk a zvýšila proliferační a cytolytický potenciál CD45+ TIL. Tyto výsledky ukazují, že IL-12 produkující buněčné vakcíny jsou schopny restaurovat cytolytický potenciál TIL a inhibovat jejich imunosupresivní účinky. (cs)
- We have examined the effect of IL-12-producing cellular vaccines on the cytotoxicity and proliferative potential of CD45+ tumour-infiltrating cells (TIL) in mice carrying syngeneic, HPV 16-associated tumours after chemotherapy with CBM-4A ifosfamide derivative. The chemotherapy resulted in decrease of the CD4+ and CD8+ TIL, increase of the Gr-1+/CD11b+ TIL, no changes in the infiltration with CD4+/CD25+ Treg TIL, and decrease of the cytolytic and proliferative potential of the CD45+ TIL. Subsequent immunotherapy with the IL-12-producing, genetically modified TC-1 cells increased tumour infiltration with CD8+ and CD4+ cells, decreased the Gr-1+/CD11b+ cells, and increased the cytolytic and proliferative potential of the CD45+ TIL. These findings suggest that peritumoral administration of the IL-12-producing cellular vaccine can restore the cytolytic potential and inhibit immunosuppressive TIL-dependent mechanisms.
- We have examined the effect of IL-12-producing cellular vaccines on the cytotoxicity and proliferative potential of CD45+ tumour-infiltrating cells (TIL) in mice carrying syngeneic, HPV 16-associated tumours after chemotherapy with CBM-4A ifosfamide derivative. The chemotherapy resulted in decrease of the CD4+ and CD8+ TIL, increase of the Gr-1+/CD11b+ TIL, no changes in the infiltration with CD4+/CD25+ Treg TIL, and decrease of the cytolytic and proliferative potential of the CD45+ TIL. Subsequent immunotherapy with the IL-12-producing, genetically modified TC-1 cells increased tumour infiltration with CD8+ and CD4+ cells, decreased the Gr-1+/CD11b+ cells, and increased the cytolytic and proliferative potential of the CD45+ TIL. These findings suggest that peritumoral administration of the IL-12-producing cellular vaccine can restore the cytolytic potential and inhibit immunosuppressive TIL-dependent mechanisms. (en)
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| Title
| - HPV 16-associated tumours: IL-12 can repair the absence of cytotoxic and proliferative responses of tumour infiltrating cells after chemotherapy
- HPV 16-asociované nádory: IL-12 může obnovit cytotoxické a proliferační odpovědi buněk infiltrujících nádor po chemoterapii (cs)
- HPV 16-associated tumours: IL-12 can repair the absence of cytotoxic and proliferative responses of tumour infiltrating cells after chemotherapy (en)
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| skos:prefLabel
| - HPV 16-associated tumours: IL-12 can repair the absence of cytotoxic and proliferative responses of tumour infiltrating cells after chemotherapy
- HPV 16-asociované nádory: IL-12 může obnovit cytotoxické a proliferační odpovědi buněk infiltrujících nádor po chemoterapii (cs)
- HPV 16-associated tumours: IL-12 can repair the absence of cytotoxic and proliferative responses of tumour infiltrating cells after chemotherapy (en)
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| skos:notation
| - RIV/68378050:_____/09:00318305!RIV09-AV0-68378050
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA301/06/0774), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/09:00318305
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - HPV 16; vaccines; tumour-infiltrating cells (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - International Journal of Oncology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Reiniš, Milan
- Bieblová, Jana
- Bubeník, Jan
- Indrová, Marie
- Pajtasz-Piasecka, E.
- Rossowska, J.
- Kuropka, P.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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