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| Description
| - X-ray diffraction analysis is still the most important method for crystal structure determination, namely of small molecules and proteins. While principles of both applications are the same, methodology of crystallization and utilization differs. Major limitation is preparation of single crystals. Current methods and trends presented at the last European Crystallographic Meeting and Congress of the International Union of Crystallography are reviewed. Crystallography of small molecules aims at solving structures from powder diffraction data, studying structural changes in chemical reactions in situ and describing detailed structure (aperiodic crystals). Advanced %22charge-flipping%22 method for the phase problem solution is mentioned. Solving crystal structures of proteins is easier with novel procedures for their supply, crystallization tests, and data collection using common and synchrotron x-ray sources with advanced computational methods of phase determination and model refinement.
- X-ray diffraction analysis is still the most important method for crystal structure determination, namely of small molecules and proteins. While principles of both applications are the same, methodology of crystallization and utilization differs. Major limitation is preparation of single crystals. Current methods and trends presented at the last European Crystallographic Meeting and Congress of the International Union of Crystallography are reviewed. Crystallography of small molecules aims at solving structures from powder diffraction data, studying structural changes in chemical reactions in situ and describing detailed structure (aperiodic crystals). Advanced %22charge-flipping%22 method for the phase problem solution is mentioned. Solving crystal structures of proteins is easier with novel procedures for their supply, crystallization tests, and data collection using common and synchrotron x-ray sources with advanced computational methods of phase determination and model refinement. (en)
- RTG strukturní analýza je stále nejdůležitější pro určování krystalové struktury látek. Je užívána v krystalografii malých molekul i proteinů. Ačkoli principy obou aplikací jsou stejné, liší se v metodologii krystalizace a užití. Hlavním omezením metody je preparace monokrystalů. Tento článek shrnuje současné metody a trendy prezentované na posledním Evropském krystalografickém meetingu a na posledním kongresu Mezinárorodní krystaligrafické unie. Krystalografie malých molekul stále více využívá metody řešení struktur z práškové difrakce pro studium strukturní změny během chemických reakcí „in situ“ a detailní popis struktury (např. aperiodické systémy). Je též zmíněna metoda „charge-flipping“, pokročilá metoda řešení fázového problému malých molekul. V metodách proteinové krystalografie jsou zmíněny pokroky v přípravě proteinů, testování krystalizačních podmínek, sběr dat, vyžití sychrotronového záření a pokročilé výpočetní metody řešení fázového problému a upřesňování struktur. (cs)
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| Title
| - What is proposed by current X-ray structural analysis?
- What is proposed by current X-ray structural analysis? (en)
- Co nabízí současná RTG analýza? (cs)
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| skos:prefLabel
| - What is proposed by current X-ray structural analysis?
- What is proposed by current X-ray structural analysis? (en)
- Co nabízí současná RTG analýza? (cs)
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| skos:notation
| - RIV/68378050:_____/08:00321880!RIV09-AV0-68378050
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/08:00321880
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - powder diffraction data; protein crystallography; molecular replacement; crystal - structures; HIV-1 protease (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Brynda, Jiří
- Kratochvíl, B.
- Sedláček, Juraj
- Hušák, M.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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