About: Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces

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About: Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Highly metastatic and nonmetastatic cells were compared in the level of Rho/ROCK signaling. The metastatic cells exhibited up-regulation of this signaling, which leads to increased ivasion, increased cytoskeletal dynamis, and increased tractions at the leading edge of the cells. Even the cells of mesenchymal origin can use the ameboid mode of invasion in dependence on the Rho/ROCK signalling. Highly metastatic and nonmetastatic cells were compared in the level of Rho/ROCK signaling. The metastatic cells exhibited up-regulation of this signaling, which leads to increased ivasion, increased cytoskeletal dynamis, and increased tractions at the leading edge of the cells. Even the cells of mesenchymal origin can use the ameboid mode of invasion in dependence on the Rho/ROCK signalling. (en) Srovnávali jsme úroveň signálu Rho/ROCK ve vysoce metastatických buňkách a v parentálních buňkách bez metastázovací aktivity. Metastatické buňky vykazují vyšší úroveň signálu Rho/ROCK společně se zvýšenou dynamikou cytoskeletu a zvýšenou tažnou silou vodicí lamely. Ukazuje se tedy, že i buňky mesenchymálního původu jsou schopny améboidního pohybu, který je pro mesenchym netypický, v závislosti na signálu přes Rho/ROCK. (cs)
Title	Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces (en) Regulace signálu Rho/ROCK v sarkomových buňkách řídí invazi a vytváření výběžků (cs)
skos:prefLabel	Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces (en) Regulace signálu Rho/ROCK v sarkomových buňkách řídí invazi a vytváření výběžků (cs)
skos:notation	RIV/68378050:_____/08:00318326!RIV09-AV0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/06/1147), Z(AV0Z50520514), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Veselý, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	401600
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/08:00318326
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Rho kinase ROCK; traction force microscopy; ameboid invasion (en)
http://linked.open.../riv/klicoveSlovo	Rho kinase ROCK ameboid invasion traction force microscopy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2321C90290C1]
http://linked.open...i/riv/nazevZdroje	Molecular Cancer Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of PI3 kinase - mTOR signaling in CAS-mediated invasiveness of Src-transformed cells
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Veselý, Pavel Bicanova, K. Brabek, J. Rosel, D. Tolde, O. Folk, P. Mierke, C. T. Fabry, B. Kollmannsberger, P. Pánková, D. Raupach, C. Zitterbart, D. P.
http://linked.open...ain/vavai/riv/wos	000260017800003
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Signaling and cellular response mechanisms
issn	1541-7786
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces

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