About: Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis

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About: Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The chemokine receptor CCR2 is highly expressed on monocyes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with monoclonal antibody during progression of collagen-induced arthritis results in massive aggravation of the disease. In this study we investigated vhy CCR2 antibodies have proinflammatory effects, how these effects can be avoided, and whether CCR2+ monocytes are useful targets in the treatment of arthritis. The chemokine receptor CCR2 is highly expressed on monocyes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with monoclonal antibody during progression of collagen-induced arthritis results in massive aggravation of the disease. In this study we investigated vhy CCR2 antibodies have proinflammatory effects, how these effects can be avoided, and whether CCR2+ monocytes are useful targets in the treatment of arthritis. (en) Chemokinový receptor CCR2 je vysoce exprimován na monocytech a zdá se být slibným terčem pro léčbu reumatické arthritidy. Blokování CCR2 monoklonální protilátkou při arthritidě vyvolané kolagenem však vede k masivnímu zhoršení této choroby. V této studii jsme sledovali, proč protilátky CCR2+ mají prozánětlivé účinky, jak se těmto účinkům lze vyhnout a zda jsou monocyty CCR2+ dobrými terči pro léčbu arthritidy. (cs)
Title	Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis Cílení Gr-1+,CCR2+ monocytů u arthritidy vyvolané kolagenem (cs) Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis (en)
skos:prefLabel	Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis Cílení Gr-1+,CCR2+ monocytů u arthritidy vyvolané kolagenem (cs) Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis (en)
skos:notation	RIV/68378050:_____/07:00097943!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany	2975;2985
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Plachý, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	454163
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/07:00097943
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	arthritis; CCR2; monocytes (en)
http://linked.open.../riv/klicoveSlovo	CCR2 arthritis monocytes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6DD9F0D9FB88]
http://linked.open...i/riv/nazevZdroje	Arthritis and Rheumatism
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Plachý, Jiří Gomez, M. R. Cihak, J. Mack, M. Stangassinger, M. Talke, Y. Denzel, A. Niedermeier, M. Brühl, H. Luckow, B. Kunz-Schughart, L.
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0004-3591
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis

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