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| rdf:type
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| Description
| - Ankylosing enthesopathy (ANKENT) is a naturally occurring arthropathy in mice with some features similar to those of the spodyloarthropathies in humans. One of relative risk factor for ANKENT and human ankylosing spondylitis (AS) is gender. Therefore, the role of sexual dimorphism and testosterone in the development of disease was studied. The incidence of ANKENT was observed in non-castrated, castrated and testosterone-substituted castrated male mice, and in control and testosterone-treated female mice. ANKENT occurred only in males and castrated males injected with testosterone. Castrated males, control females and testosterone-injected females did not develop ANKENT. Testosterone can replace what castration eliminates, but is itself not sufficient to induce joint disease.
- Ankylosing enthesopathy (ANKENT) is a naturally occurring arthropathy in mice with some features similar to those of the spodyloarthropathies in humans. One of relative risk factor for ANKENT and human ankylosing spondylitis (AS) is gender. Therefore, the role of sexual dimorphism and testosterone in the development of disease was studied. The incidence of ANKENT was observed in non-castrated, castrated and testosterone-substituted castrated male mice, and in control and testosterone-treated female mice. ANKENT occurred only in males and castrated males injected with testosterone. Castrated males, control females and testosterone-injected females did not develop ANKENT. Testosterone can replace what castration eliminates, but is itself not sufficient to induce joint disease. (en)
- Ankylosující enthesopathie (ANKENT), která se přirozeně vyskytuje u myší, má některé shodné vlastnosti se spondyloartrhropathiemi u člověka. Relativním rizikovým faktorem pro ANKENT a lidskou ankylosující spondylitidu (AS) je pohlaví. ANKENT se vyskytuje pouze u samců, AS převážně u mužů (75% případů). Proto byla studována úloha pohlavního dimorfismu a testosteronu při vzniku nemoci. ANKENT byl sledován u nekastrovaných, kastrovaných a testosteronem substituovaných kastrovaných myších samců a kontrolních a testosteronem injikovaných myších samic. Nemoc se vyskytla pouze u samců a kastrovaných samců injikovaných testosteronem. Kastrovaní samci, kontrolní samice a samice injikované testosteronem ANKENT neměli. Testosteron nahradil to, co bylo odstraněno kastrací, ale sám o sobě nemoc nevyvolal. (cs)
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| Title
| - Sexual dimorphism, but not testosterone itself, is responsible for ankylosing enthesitis of the ankle in B10.BR(H-2k) male mice
- Pohlavní dimorfismus, ale nikoliv samotný testosteron, je odpovědný za ankylosující enthesitidu kotníku u B10.BR(H-2k) u myších samců (cs)
- Sexual dimorphism, but not testosterone itself, is responsible for ankylosing enthesitis of the ankle in B10.BR(H-2k) male mice (en)
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| skos:prefLabel
| - Sexual dimorphism, but not testosterone itself, is responsible for ankylosing enthesitis of the ankle in B10.BR(H-2k) male mice
- Pohlavní dimorfismus, ale nikoliv samotný testosteron, je odpovědný za ankylosující enthesitidu kotníku u B10.BR(H-2k) u myších samců (cs)
- Sexual dimorphism, but not testosterone itself, is responsible for ankylosing enthesitis of the ankle in B10.BR(H-2k) male mice (en)
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| skos:notation
| - RIV/68378050:_____/06:00048550!RIV07-GA0-68378050
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA305/03/0287), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/06:00048550
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - ankylosing enthesopathy; ankylosing spondylitis; testosterone (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Annals of the Rheumatic Diseases
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Čapková, Jana
- Řeháková, Z.
- Ivanyi, P.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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