About: Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.

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About: Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Alpha-Tocopheryl succinate (alpha-TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas alpha-tocopherol (alpha-TOH) lacks apoptogenic activity. Here we investigated the possible antineoplastic activities of alpha-TOH and alpha-TOS and further explored the potential of alpha-TOS as an antitumor agent. Using nude mice with colon cancer xenografts, we found that alpha -TOH exerted modest antitumor activity and acted by inhibiting tumor cell proliferation. In contrast, alpha -TOS showed a more profound antitumor effect, at both the level of inhibition of proliferation and induction of tumor cell apoptosis. Alpha-TOS was nontoxic to normal cells and tissues, triggered apoptosis in p53-/-and p21Waf1/Cip1(-/-) cancer cells. Vitamin E succinate is thus a potent and highly specific anticancer agent and/or adjuvant of considerable therapeutic potential. Alpha-Tocopheryl succinate (alpha-TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas alpha-tocopherol (alpha-TOH) lacks apoptogenic activity. Here we investigated the possible antineoplastic activities of alpha-TOH and alpha-TOS and further explored the potential of alpha-TOS as an antitumor agent. Using nude mice with colon cancer xenografts, we found that alpha -TOH exerted modest antitumor activity and acted by inhibiting tumor cell proliferation. In contrast, alpha -TOS showed a more profound antitumor effect, at both the level of inhibition of proliferation and induction of tumor cell apoptosis. Alpha-TOS was nontoxic to normal cells and tissues, triggered apoptosis in p53-/-and p21Waf1/Cip1(-/-) cancer cells. Vitamin E succinate is thus a potent and highly specific anticancer agent and/or adjuvant of considerable therapeutic potential. (en)
Title	Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. (en)
skos:prefLabel	Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. (en)
skos:notation	RIV/68378050:_____/02:23033196!RIV/2004/GA0/A23004/N
http://linked.open.../vavai/riv/strany	863;869
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/99/0350), P(GA312/99/0348), P(IAA5052001), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Anděra, Ladislav Kořínek, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	668738
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/02:23033196
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Vitamin E, Antineoplastic Agent, Tumor Necrosis Factor (en)
http://linked.open.../riv/klicoveSlovo	Antineoplastic Agent Tumor Necrosis Factor Vitamin E
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B7B11CF3475C]
http://linked.open...i/riv/nazevZdroje	Clinical Cancer Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	16 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Screening for and characterization of novel, apoptosis inducing surface molecules of human hematopoietic cells Molecular mechanisms regulating development and malignant transformation of intestinal tissues Characterization and potential therapeutical use of TRAIL-mediated apoptosis
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Anděra, Ladislav Weber, T. Kořínek, Vladimír Lu, M. Neužil, J. Weber, C. Gellert, N. Brunk, U. T. Coffey, R. J. Erl, W. Fariss, M. W. Lahm, H. Sattler, W. Schroder, A. Terman, A. Ucker, D. S.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	1078-0432
number of pages	7 (xsd:int)

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