About: Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection.     Goto   Sponge   NotDistinct   Permalink

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  • Generation of free radicals is often associated with the induction of apoptosis. Exposure of Jurkat cells to alpha-tocopheryl succinate (alpha-TOS), hydrogen peroxide (HP), anti-Fas IgM or TRAIL led to apoptosis. The reduced form of coenzyme Q suppressed cell death due to the chemical agents. However, coenzyme did not block apoptosis induced by anti-Fas IgM or TRAIL. Ubiquinol-10 inhibited ROS generation in cells exposed to alpha-TOS, and mitochondrially-targeted coenzyme Q analogue blocked apoptosis induced by alpha-TOS.
  • Generation of free radicals is often associated with the induction of apoptosis. Exposure of Jurkat cells to alpha-tocopheryl succinate (alpha-TOS), hydrogen peroxide (HP), anti-Fas IgM or TRAIL led to apoptosis. The reduced form of coenzyme Q suppressed cell death due to the chemical agents. However, coenzyme did not block apoptosis induced by anti-Fas IgM or TRAIL. Ubiquinol-10 inhibited ROS generation in cells exposed to alpha-TOS, and mitochondrially-targeted coenzyme Q analogue blocked apoptosis induced by alpha-TOS. (en)
Title
  • Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection.
  • Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection. (en)
skos:prefLabel
  • Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection.
  • Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection. (en)
skos:notation
  • RIV/68378050:_____/01:23010356!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany
  • 46;50
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA301/99/0350), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 675822
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/01:23010356
http://linked.open...riv/jazykVysledku
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  • coenzyme Q; - apoptosis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [4F3F762228BE]
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  • FEBS Letters
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 503
http://linked.open...iv/tvurceVysledku
  • Alleva, R.
  • Anděra, Ladislav
  • Borghi, B.
  • Tomasetti, M.
  • Neužil, J.
  • Weber, C.
  • Murphy, M. P.
  • Gellert, N.
http://linked.open...n/vavai/riv/zamer
issn
  • 0014-5793
number of pages
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