About: The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The expression of TRPV4 is markedly enhanced in adult rat hippocampal astrocytes of the CA1 region after hypoxia/ischemia coinciding with the development of astrogliosis. This was revealed by immunohistochemical analyses, patch-clamp and calcium imaging measurements both in vitro and in situ. Collectively, we show that TRPV4 channels are involved in ischemia induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult. The expression of TRPV4 is markedly enhanced in adult rat hippocampal astrocytes of the CA1 region after hypoxia/ischemia coinciding with the development of astrogliosis. This was revealed by immunohistochemical analyses, patch-clamp and calcium imaging measurements both in vitro and in situ. Collectively, we show that TRPV4 channels are involved in ischemia induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult. (en)
Title	The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia (en)
skos:prefLabel	The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia (en)
skos:notation	RIV/68378041:_____/12:00377854!RIV13-AV0-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP303/10/1338), P(GD309/08/H079), P(LC554), Z(AV0Z50390512), Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Anděrová, Miroslava Benešová, Jana Honsa, Pavel Džamba, Dávid Butenko, Olena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	141107
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/12:00377854
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ischemia; astrocytes; transient receptor channel (en)
http://linked.open.../riv/klicoveSlovo	ischemia astrocytes transient receptor channel
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[78C5BC8146A6]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	PhD program in neuroscience Neuroscience Centre Cell volume regulation in glial cells during brain ischemia/reperfusion
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Benešová, Jana Rusňáková, Vendula Anděrová, Miroslava Džamba, Dávid Honsa, Pavel Benfenati, V. Butenko, Olena Ferroni, S.
http://linked.open...ain/vavai/riv/wos	000305825800082
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie Establishing of the Biotechnology Institute ASCR
issn	1932-6203
number of pages	23 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0039959
is http://linked.open...avai/riv/vysledek of	The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia

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