About: Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Toxic effects of complex mixtures of organic extracts from urban particles (PM2.5) collected at 4 localities with different extent of air pollution (Ostrava-Bartovice, Ostrava-Poruba, Karviná a Třeboň) were evaluated. For this purpose, human embryonic lung fibroblasts (HEL 12469) were used. Global gene expression changes were analyzed using human whole genome microarrays (Illumina). The transcriptomic data did not differ substantially between the localities, suggesting that the air pollution originating mainly from various sources may have similar biological effects. Toxic effects of complex mixtures of organic extracts from urban particles (PM2.5) collected at 4 localities with different extent of air pollution (Ostrava-Bartovice, Ostrava-Poruba, Karviná a Třeboň) were evaluated. For this purpose, human embryonic lung fibroblasts (HEL 12469) were used. Global gene expression changes were analyzed using human whole genome microarrays (Illumina). The transcriptomic data did not differ substantially between the localities, suggesting that the air pollution originating mainly from various sources may have similar biological effects. (en)
Title	Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles (en)
skos:prefLabel	Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles (en)
skos:notation	RIV/68378041:_____/12:00377763!RIV13-AV0-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(2B08005), P(GAP503/11/0142), Z(AV0Z50390512), Z(AV0Z50390703), Z(MSM6840770012)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Šrám, Radim Topinka, Jan Uhlířová, Kateřina Líbalová, Helena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	138199
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/12:00377763
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	air pollution; complex mixtures; HEL cells (en)
http://linked.open.../riv/klicoveSlovo	HEL cells complex mixtures air pollution
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D93502E538A2]
http://linked.open...i/riv/nazevZdroje	Particle and Fibre Toxicology
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants. Genotoxic and non-genotoxic mechanisms involved in carcinogenicity of complex mixtures of air pollutants: toxicogenomic approach
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Ciganek, M. Machala, M. Topinka, Jan Uhlířová, Kateřina Šrám, Radim Líbalová, Helena Kléma, J.
http://linked.open...ain/vavai/riv/wos	000301574500001
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Transdisciplinární výzkum v oblasti biomedicínského inženýrství II
issn	1743-8977
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1743-8977-9-1
is http://linked.open...avai/riv/vysledek of	Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles

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