About: Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering

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Description	Poly(N,N-diethylacrylamide) (PDEAAm) hydrogel scaffolds were prepared by radical copolymerization of N,Ndiethylacrylamide (DEAAm), N,N0-methylenebisacrylamide and methacrylic acid in the presence of (NH4)2SO4 or NaCl. The hydrogels were characterized by low-vacuum scanning electron microscopy in the water-swollen state, water and cyclohexane regain, and by mercury porosimetry. The pentapeptide, YIGSR-NH2, was immobilized on the hydrogel. Human embryonic stem cells (hESCs) were cultured with the hydrogels to test their biocompatibility. The results suggest that the PDEAAm hydrogel scaffolds are nontoxic and support hESC attachment and proliferation, and that interconnected pores of the scaffolds are important for hESC cultivation. Immobilization of YIGSR-NH2 pentapeptide on the PDEAAm surface improved both adhesion and growth of hESCs compared with the unmodified hydrogel. The YIGSRNH2- modified PDEAAm hydrogels may be a useful tool for tissue-engineering purposes. Poly(N,N-diethylacrylamide) (PDEAAm) hydrogel scaffolds were prepared by radical copolymerization of N,Ndiethylacrylamide (DEAAm), N,N0-methylenebisacrylamide and methacrylic acid in the presence of (NH4)2SO4 or NaCl. The hydrogels were characterized by low-vacuum scanning electron microscopy in the water-swollen state, water and cyclohexane regain, and by mercury porosimetry. The pentapeptide, YIGSR-NH2, was immobilized on the hydrogel. Human embryonic stem cells (hESCs) were cultured with the hydrogels to test their biocompatibility. The results suggest that the PDEAAm hydrogel scaffolds are nontoxic and support hESC attachment and proliferation, and that interconnected pores of the scaffolds are important for hESC cultivation. Immobilization of YIGSR-NH2 pentapeptide on the PDEAAm surface improved both adhesion and growth of hESCs compared with the unmodified hydrogel. The YIGSRNH2- modified PDEAAm hydrogels may be a useful tool for tissue-engineering purposes. (en)
Title	Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering (en)
skos:prefLabel	Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering (en)
skos:notation	RIV/68378041:_____/11:00360755!RIV12-AV0-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GAP304/11/0731), P(LC06077), Z(AV0Z40500505), Z(AV0Z50390512), Z(AV0Z50390703), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hampl, Aleš Dvořák, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	219864
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00360755
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	poly(N,N-diethylacrylamide); porosity; YIGSR peptide (en)
http://linked.open.../riv/klicoveSlovo	porosity N-diethylacrylamide) YIGSR peptide poly(N
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[492B1FB5CE9C]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedical Materials Research. Part B
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair Center of Chemical Genetics Spinal cord injury repair using biomodified hydrogels with oriented channels
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	98B
http://linked.open...iv/tvurceVysledku	Dvořák, Petr Hampl, Aleš Horák, Daniel Beneš, Milan J. Lapčíková, Monika Hlídková, Helena Jaroš, J. Matulka, K.
http://linked.open...ain/vavai/riv/wos	000291598900007
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1552-4973
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jbm.b.31832
is http://linked.open...avai/riv/vysledek of	Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering

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