About: Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein

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About: Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have descibed for the first time that histone deacetylases (HDAC) inhibitors (trichostatin A, sodium butyrate, MS-275, SAHA, and valproic acid) supress interferon alpha (IFN alpha)-induced up regulation of promyelocytic leukemia protein (PML) at mRNA and protein levels in several human cell lines and in normal diploid skin fibroblasts. Additionaly, HDAC inhibitors blocked an increase of PML nuclear bodies number in response to IFN (alpha)-stimulation. We showed that the effect of HDAC inhibitors on IFN (alpha)-pathway is STAT2- independent. We have descibed for the first time that histone deacetylases (HDAC) inhibitors (trichostatin A, sodium butyrate, MS-275, SAHA, and valproic acid) supress interferon alpha (IFN alpha)-induced up regulation of promyelocytic leukemia protein (PML) at mRNA and protein levels in several human cell lines and in normal diploid skin fibroblasts. Additionaly, HDAC inhibitors blocked an increase of PML nuclear bodies number in response to IFN (alpha)-stimulation. We showed that the effect of HDAC inhibitors on IFN (alpha)-pathway is STAT2- independent. (en) Jako první jsme popsali, že inhibitory histondeacetyláz (trichostatin A, butyrát sodný, MS-275, SAHA a kyselina valproová) suprimují interferonem alfa (IFN alfa) zprostředkovanou indukci promyelocytárního leukemia proteinu (PML) na úrovni mRNA a proteinu v několika lidských buněčných liniích a v normálních diploidních kožních fibroblastech. Dále inhibitory histondeacetyláz blokovaly nárust počtu PML jaderných tělísek po stimulaci IFN alfa. Prokázali jsme, že efekt histondeacetylázových inhibitorů na IFN alfa dráhu je nezavislý na STAT2. (cs)
Title	Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein Inhibitory histondeacetyláz suprimují IFN(alfa)-indukovanou up-regulaci promyelocytarního leukemia proteinu (cs) Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein (en)
skos:prefLabel	Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein Inhibitory histondeacetyláz suprimují IFN(alfa)-indukovanou up-regulaci promyelocytarního leukemia proteinu (cs) Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein (en)
skos:notation	RIV/68378041:_____/07:00083219!RIV07-AV0-68378041
http://linked.open.../vavai/riv/strany	1373;1380
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/03/1210), P(GEDYN/04/E002), P(IAA500390501), Z(AV0Z50390512), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Nováková, Zora Rossmeislová, Lenka Hozák, Pavel Hodný, Zdeněk Kahle, Michal Dobrovolná, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	424196
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/07:00083219
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Acute promyelocytic leukemia (en)
http://linked.open.../riv/klicoveSlovo	Acute promyelocytic leukemia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BE97D3C9415B]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Control of stress and interferon regulated gene expression by transcription factors, histone modification and nuclear compartmentalization Nuclear compartmentalization of nuclear DNA helicase II in relationship to gene expression and cellular senescence The role of PML in cellular senescence
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	109
http://linked.open...iv/tvurceVysledku	Hozák, Pavel Rossmeislová, Lenka Hodný, Zdeněk Kahle, Michal Nováková, Zora Vlasáková, Jana
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0006-4971
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein

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