About: Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity

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About: Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We found that mutp53 preferentially and autonomously binds to G/C-rich DNA around transcription start sites of many genes characterized by active chromatin marks and frequently associated with transcription-competent RNA polymerase II. Also mutp53 binds and stabilizes a well-characterized G-quadruplex structure in vitro. We found that mutp53 preferentially and autonomously binds to G/C-rich DNA around transcription start sites of many genes characterized by active chromatin marks and frequently associated with transcription-competent RNA polymerase II. Also mutp53 binds and stabilizes a well-characterized G-quadruplex structure in vitro. (en)
Title	Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity (en)
skos:prefLabel	Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity (en)
skos:notation	RIV/68081707:_____/12:00383544!RIV13-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(GAP301/10/2370), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kejnovská, Iva Brázdová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	152540
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/12:00383544
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mutant p53; transcription; G-quadruplex (en)
http://linked.open.../riv/klicoveSlovo	transcription G-quadruplex mutant p53
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8BE5518BFB82]
http://linked.open...i/riv/nazevZdroje	Cell Cycle
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology The role of p53 DNA structure-selective binding in brain cancer
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Brázdová, Marie Kejnovská, Iva Deppert, W. Otto, B. Quante, T. Tolstonog, G. V.
http://linked.open...ain/vavai/riv/wos	000308750600025
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1538-4101
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.4161/cc.21646
is http://linked.open...avai/riv/vysledek of	Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity

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