About: Preferential binding of IFI16 protein to cruciform structure and superhelical DNA

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Interferon (IFN)-inducible HIN-200 proteins play an important role in transcriptional regulation linked to cell cycle control, inflammation, autoimmunity and differentiation. We demonstrate that IFI16 protein binds strongly to negatively superhelical plasmid DNA. We also detect a strong preference for IFI16 binding to cruciform DNA structure compared to linear DNA topology. This novel DNA-binding property of IFI16 protein to scDNA and cruciform structures may play critical roles in its tumor suppressor function. Interferon (IFN)-inducible HIN-200 proteins play an important role in transcriptional regulation linked to cell cycle control, inflammation, autoimmunity and differentiation. We demonstrate that IFI16 protein binds strongly to negatively superhelical plasmid DNA. We also detect a strong preference for IFI16 binding to cruciform DNA structure compared to linear DNA topology. This novel DNA-binding property of IFI16 protein to scDNA and cruciform structures may play critical roles in its tumor suppressor function. (en)
Title	Preferential binding of IFI16 protein to cruciform structure and superhelical DNA Preferential binding of IFI16 protein to cruciform structure and superhelical DNA (en)
skos:prefLabel	Preferential binding of IFI16 protein to cruciform structure and superhelical DNA Preferential binding of IFI16 protein to cruciform structure and superhelical DNA (en)
skos:notation	RIV/68081707:_____/12:00379230!RIV13-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP301/10/1211), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Brázda, Václav Coufal, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	161198
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/12:00379230
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cruciform structure; IFI16; protein-DNA binding (en)
http://linked.open.../riv/klicoveSlovo	cruciform structure protein-DNA binding IFI16
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[06E5DA7389EF]
http://linked.open...i/riv/nazevZdroje	Biochemical and Biophysical Research Communications
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Transcriptional activities of wild-type and mutant p53, decision between cell proliferation, cell cycle arrest and apoptosis
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	422
http://linked.open...iv/tvurceVysledku	Brázda, Václav Coufal, Jan Arrowsmith, Ch. H. Liao, J.C.C.
http://linked.open...ain/vavai/riv/wos	000306443900033
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0006-291X
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbrc.2012.05.065
is http://linked.open...avai/riv/vysledek of	Preferential binding of IFI16 protein to cruciform structure and superhelical DNA

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