About: Effect of H1-antihistamines on the oxidative burst of rat phagocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Phagocytosis is the essential defensive mechanism against microbial pathogens. This function is ensured by several types of cells with neutrophils in the lead. Phagocyte-derived reactive oxygen species (ROS) belong to the basic microbicidal mechanisms. As observed in our previous study, H1-antagonist dithiaden inhibits the production of ROS by phagocytes. The aim of this study was to compare the inhibition effect of dithiaden with effects of four selected H1-antihistamines of the 2nd generation - loratadine, acrivastine, astemizole and ketotifen fumarate. Acrivastine and loratadine do not suppress the key microbicidal system of phagocytes, ketotifen fumarate inhibited the respiratory burst of phagocytes similarly to dithiaden. Astemizol showed even higher inhibition effect in comparison with dithiaden. Phagocytosis is the essential defensive mechanism against microbial pathogens. This function is ensured by several types of cells with neutrophils in the lead. Phagocyte-derived reactive oxygen species (ROS) belong to the basic microbicidal mechanisms. As observed in our previous study, H1-antagonist dithiaden inhibits the production of ROS by phagocytes. The aim of this study was to compare the inhibition effect of dithiaden with effects of four selected H1-antihistamines of the 2nd generation - loratadine, acrivastine, astemizole and ketotifen fumarate. Acrivastine and loratadine do not suppress the key microbicidal system of phagocytes, ketotifen fumarate inhibited the respiratory burst of phagocytes similarly to dithiaden. Astemizol showed even higher inhibition effect in comparison with dithiaden. (en) Fagocytóza je nezbytným mechanismem proti mikrobiálním patogenům. Tato funkce je zajišťována různými typy buněk, zejména neutrofily a jimi produkované reaktivní kyslíkové metabolity (ROS) patří k základním mikrobicidním mechanismům. V předchozí studii jsme zjistili, že H1-antagonista dithiaden inhibuje produkci ROS fagocyty. Cílem této studie bylo srovnat inhibiční účinek dithiadenu se čtyřmi vybranými H1-antihistaminiky 2. generace - loratadine, acrivastinem, astemizolem a ketotifen-fumaratem. Acrivastine a loratadine nepotlačoval mikrobicidní systém fagocytů, ketotifen-fumarate inhiboval oxidativní vzplanutí podobně jako dithiadena a astemizol vykazoval silný inhibiční efekt ve srovnání s dithiadenem. (cs)
Title	Effect of H1-antihistamines on the oxidative burst of rat phagocytes Effect of H1-antihistamines on the oxidative burst of rat phagocytes (en) Účinek H1-antihistaminik na oxidativní vzplanutí potkaních fagocytů (cs)
skos:prefLabel	Effect of H1-antihistamines on the oxidative burst of rat phagocytes Effect of H1-antihistamines on the oxidative burst of rat phagocytes (en) Účinek H1-antihistaminik na oxidativní vzplanutí potkaních fagocytů (cs)
skos:notation	RIV/68081707:_____/06:00038992!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	S15;S16
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/04/0896), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Moravcová, Jana Lojek, Antonín Číž, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	473085
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/06:00038992
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	H1-antihistamines; reactive oxygen species; phagocytes (en)
http://linked.open.../riv/klicoveSlovo	reactive oxygen species phagocytes H1-antihistamines
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[39BF3B6BB173]
http://linked.open...i/riv/nazevZdroje	Inflammation Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Effects of carvedilol on metabolic activity of neutrophuls and monocytes
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Lojek, Antonín Králová, Jana Drábiková, K. Číž, Milan Nosál, R.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	1023-3830
number of pages	2 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Effect of H1-antihistamines on the oxidative burst of rat phagocytes Effect of H1-antihistamines on the oxidative burst of rat phagocytes

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