About: Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	p53 is one of the most important regulators of cell proliferation and differentiation and of programmed cell death, triggering growth arrest and/or apoptosis in response to different cellular stress signals. The sequence-specific DNA-binding function of p53 protein can be activated by several different stimuli that modulate the C-terminal domain of this protein. The predominant mechanism of activation of p53 sequence-specific DNA binding is phosphorylation at specific sites. For example, phosphorylation of p53 by PKC (protein kinase C) occurs in undamaged cells, resulting in masking of the epitope recognized by monoclonal antibody PAb421, and presumably promotes steady-state levels of p53 activity in cycling cells. In contrast, phosphorylation by cdk2 (cyclin-dependent kinase 2)/cyclin A and by the protein kinase CK2 are both enhanced in DNA-damaged cells. p53 is one of the most important regulators of cell proliferation and differentiation and of programmed cell death, triggering growth arrest and/or apoptosis in response to different cellular stress signals. The sequence-specific DNA-binding function of p53 protein can be activated by several different stimuli that modulate the C-terminal domain of this protein. The predominant mechanism of activation of p53 sequence-specific DNA binding is phosphorylation at specific sites. For example, phosphorylation of p53 by PKC (protein kinase C) occurs in undamaged cells, resulting in masking of the epitope recognized by monoclonal antibody PAb421, and presumably promotes steady-state levels of p53 activity in cycling cells. In contrast, phosphorylation by cdk2 (cyclin-dependent kinase 2)/cyclin A and by the protein kinase CK2 are both enhanced in DNA-damaged cells. (en) Nádorový supresor protein p53 je jedním z nejdůležitějších regulátorů proliferace a diferenciace buněk a programované buněčné smrti, neboť spouští zástavu růstu a/nebo apoptosu jako odpověď na různé signály buněčného stresu. Sekvenčně specifická funkce vazby proteinu p53 na DNA může být aktivována různými stimuly, které modulují C-koncovou doménu tohoto proteinu. Převažujícím mechanismem pro aktivaci sekvenčně specifické vazby na DNA je fosforylace na specifických místech. Na příklad, fosforylace protinu p53 působením PKC (protein kinázy C) se objevuje v nepoškozených buňkách a výsledkem je maskování epitopu, který je rozpoznáván protilátkou PAb421, a pravděpodobně podporuje rovnovážné hladiny aktivity p53 během buněčného cyklu. Na rozdíl od tohoto, fosforylace působením cdk2 (cyklin dependentní kináza 2)/cyklin A a protein kinázou CK2 je obojí zvýrazněno v buňkách s poškozenou DNA. (cs)
Title	Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2 Aktivace schopnosti vázat se na DNA latentního p53 protein kinázou C se ruší protein kinázou CK2 (cs) Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2 (en)
skos:prefLabel	Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2 Aktivace schopnosti vázat se na DNA latentního p53 protein kinázou C se ruší protein kinázou CK2 (cs) Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2 (en)
skos:notation	RIV/68081707:_____/04:00104694!RIV/2005/AV0/A17005/N
http://linked.open.../vavai/riv/strany	939;947
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/00/D001), P(GA301/00/P094), P(GA301/02/0831), P(IAB5004203), P(OC 518.30), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Cahová, Kateřina Paleček, Emil Brázda, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	553452
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/04:00104694
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	activation; cdk2/cyclin A; DNA binding (en)
http://linked.open.../riv/klicoveSlovo	activation cdk2/cyclin A DNA binding
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[52D1D4F94436]
http://linked.open...i/riv/nazevZdroje	Biochemical Journal
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Interactions of p53 protein and its homologues with DNA and their role in malignant transformation Binding of human and mouse tumour suppressor protein p53 to linear and supercoiled DNAs The study of mechanisms regulating the activity of p53 protein and the possibilities of its latent forms activation in cancer cell Regulation of transcription factors binding to consensus sequences in superhelical DNA. Influence of phosphorylation of tumor supressor proteins http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20518.30
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	378
http://linked.open...iv/tvurceVysledku	Brázda, Václav Paleček, Emil Pospíšilová, Š. Skládal, P. Vojtěšek, B. Kuchaříková, Kateřina Hupp, T. R. Luciani, M. G.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0264-6021
number of pages	9 (xsd:int)

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