About: Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding

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About: Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the present work the DNA binding of [{trans-PtCl(NH3)2}2m-cis-Pt(NH3)2{H2N(CH2)6NH2}2]4+ (1,0,1/t,c,t) in cell-free media was examined by the methods of molecular biophysics and compared to the binding of 1,0,1/t,t,t. The binding of 1,0,1/t,c,t is slower and less sequence specific. 1,0,1/t,c,t also forms on DNA long-range delocalized intrastrand and interstrand cross-links similarly as 1,0,1/t,t,t, although the frequency of interstrand adducts is markedly enhanced. Importantly, the adducts of 1,0,1/t,c,t distort DNA conformation and are repaired by cell-free extracts considerably more than the adducts of 1,0,1/t,t,t. It has been suggested that the unique properties of long-range interstrand cross-links of bifunctional trinuclear platinum complexes and resulting conformational alterations in DNA have critical consequences for their antitumor effects. In the present work the DNA binding of [{trans-PtCl(NH3)2}2m-cis-Pt(NH3)2{H2N(CH2)6NH2}2]4+ (1,0,1/t,c,t) in cell-free media was examined by the methods of molecular biophysics and compared to the binding of 1,0,1/t,t,t. The binding of 1,0,1/t,c,t is slower and less sequence specific. 1,0,1/t,c,t also forms on DNA long-range delocalized intrastrand and interstrand cross-links similarly as 1,0,1/t,t,t, although the frequency of interstrand adducts is markedly enhanced. Importantly, the adducts of 1,0,1/t,c,t distort DNA conformation and are repaired by cell-free extracts considerably more than the adducts of 1,0,1/t,t,t. It has been suggested that the unique properties of long-range interstrand cross-links of bifunctional trinuclear platinum complexes and resulting conformational alterations in DNA have critical consequences for their antitumor effects. (en) V této práci byla zkoumána vazba komplexů [{trans-PtCl(NH3)2}2m-cis-Pt(NH3)2{H2N(CH2)6NH2}2]4+ (1,0,1/t,c,t) na DNA v nebuněčném prostředí metodami molekulární biofyziky. Vazba je málo sekvenčně specifická a vede ke vzniku můstků dlouhého dosahu. Bylo navrženo, že unikátní vlastnosti těchto můstků vytvořených bifunkčními trojjadernými komplexy platiny a výsledné změny v konformaci DNA mají kritický význam pro protinádorovou účinnost této třídy komplexů platiny. (cs)
Title	Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding (en) Vliv geometrie centrální koordinační sféry protinádorově účinných trojjaderných komplexů platiny na jejich vazbu k DNA (cs)
skos:prefLabel	Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding (en) Vliv geometrie centrální koordinační sféry protinádorově účinných trojjaderných komplexů platiny na jejich vazbu k DNA (cs)
skos:notation	RIV/68081707:_____/04:00104641!RIV/2005/AV0/A17005/N
http://linked.open.../vavai/riv/strany	1560;1569
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/1552), P(IBS5004009), P(KJB5004301), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Vrána, Oldřich
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	562065
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/04:00104641
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; platinum; antitumor (en)
http://linked.open.../riv/klicoveSlovo	DNA platinum antitumor
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[54AB1D8191E4]
http://linked.open...i/riv/nazevZdroje	Journal of Inorganic Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Untraditional therapeutic approaches in oncology Molecular mechanisms underlying anticancer effects of a new drug BBR3464
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	98
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Vrána, Oldřich Farrell, N.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0162-0134
number of pages	10 (xsd:int)

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