About: Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro.

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About: Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effects of several synthetic adenosine receptor agonists on the growth characteristics of murine G:5:113 fibrosarcoma cells in vitro were evaluated. Cell number and viability, as well as proportions of cells in individual cell cycle phases, were determined after 48 h cultivation of the cells in the presence of concentrations of adenosine receptor agonists ranging between 0.01 and 500 muM. Effects of the non-selective adenosine receptor agonist NECA, as well as of agonists selective for A(1) (CPA), A(2A) (CGS 21680), and A(3) receptors (IB-MECA) were evaluated. A slight increase in cell number was observed at a narrow range of concentrations between 30-50 muM of NECA, which was reproduced by CPA, a selective A, receptor agonist, in concentrations ranging from 20-50 muM. The most important finding was that of significant inhibitory effects of adenosine receptor agonists on cell number in concentrations above 50 muM. The effects of several synthetic adenosine receptor agonists on the growth characteristics of murine G:5:113 fibrosarcoma cells in vitro were evaluated. Cell number and viability, as well as proportions of cells in individual cell cycle phases, were determined after 48 h cultivation of the cells in the presence of concentrations of adenosine receptor agonists ranging between 0.01 and 500 muM. Effects of the non-selective adenosine receptor agonist NECA, as well as of agonists selective for A(1) (CPA), A(2A) (CGS 21680), and A(3) receptors (IB-MECA) were evaluated. A slight increase in cell number was observed at a narrow range of concentrations between 30-50 muM of NECA, which was reproduced by CPA, a selective A, receptor agonist, in concentrations ranging from 20-50 muM. The most important finding was that of significant inhibitory effects of adenosine receptor agonists on cell number in concentrations above 50 muM. (en)
Title	Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro. Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro. (en)
skos:prefLabel	Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro. Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro. (en)
skos:notation	RIV/68081707:_____/03:17033128!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	303;311
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/0423), P(IBS5004009), P(KSK5011112), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Chramostová, Kateřina Hoferová, Zuzana Pospíšil, Milan Hofer, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	605326
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033128
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adenosine receptor agonists; fibrosarcoma; tumor cell proliferation (en)
http://linked.open.../riv/klicoveSlovo	adenosine receptor agonists tumor cell proliferation fibrosarcoma
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F4A22F143B48]
http://linked.open...i/riv/nazevZdroje	Drug Development Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The effect of adenosine analogs on hematopoiesis Molecular and cellular mechanisms of important diseases Untraditional therapeutic approaches in oncology
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Hofer, Michal Hoferová, Zuzana Pospíšil, Milan Znojil, V. Minksová, Kateřina
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0272-4391
number of pages	9 (xsd:int)

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