About: DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes.

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About: DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We examined oligodeoxyribonucleotide duplexes containing a single, site-specific, monofunctional adduct of trans-[PtCl2(E-iminoether)2] by the methods of molecular biophysics. The results indicate that major monofunctional adducts of this drug locally distort DNA, bend the DNA axis by 21o toward the minor groove, are not recognized by HMGB1 proteins and are readily removed from DNA by nucleotide excision repair (NER). In addition, the monofunctional adducts of trans-[PtCl2(E-iminoether)2] readily cross-link proteins, which markedly enhances the efficiency of this adduct to terminate DNA polymerization by DNA polymerases in vitro and to inhibit removal of this adduct from DNA by NER. It is suggested that DNA-protein ternary cross-links produced by trans-[PtCl2(E-iminoether) could persist considerably longer than the non-cross-linked monofunctional adducts, which would potentiate toxicity of this antitumor platinum compound toward tumor cells sensitive to this drug. We examined oligodeoxyribonucleotide duplexes containing a single, site-specific, monofunctional adduct of trans-[PtCl2(E-iminoether)2] by the methods of molecular biophysics. The results indicate that major monofunctional adducts of this drug locally distort DNA, bend the DNA axis by 21o toward the minor groove, are not recognized by HMGB1 proteins and are readily removed from DNA by nucleotide excision repair (NER). In addition, the monofunctional adducts of trans-[PtCl2(E-iminoether)2] readily cross-link proteins, which markedly enhances the efficiency of this adduct to terminate DNA polymerization by DNA polymerases in vitro and to inhibit removal of this adduct from DNA by NER. It is suggested that DNA-protein ternary cross-links produced by trans-[PtCl2(E-iminoether) could persist considerably longer than the non-cross-linked monofunctional adducts, which would potentiate toxicity of this antitumor platinum compound toward tumor cells sensitive to this drug. (en)
Title	DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes. DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes. (en)
skos:prefLabel	DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes. DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes. (en)
skos:notation	RIV/68081707:_____/03:17033052!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	6450;6460
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/1552), P(KJB5004301), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Nováková, Olga Malina, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	604252
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033052
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; cross-links; platinum antitumor complexes (en)
http://linked.open.../riv/klicoveSlovo	DNA platinum antitumor complexes cross-links
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[857142C27E9E]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Molecular mechanisms underlying anticancer effects of a new drug BBR3464
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Malina, Jaroslav Nováková, Olga Natile, G.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0305-1048
number of pages	11 (xsd:int)

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