About: Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues.

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About: Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Replacement of the ammine group in antitumor cisplatin by a heterocyclic ligand (piperidine, piperazine, or 4-picoline) results in reduction of cytotoxicity in human ovarian cancer cells. The results suggest that in certain cancer cells the lower cytotoxicity of cis-[PtCl2(NH3)(piperidine)] might be partially associated with reduced affinity of the high mobility group proteins to the major intrastrand cross-links of this analogue relative to the same adducts of cisplatin. The results support the view that the concept based on the design of the complexes structurally derived from cisplatin that do not present an altered DNA binding mode may be less effective in the search for new platinum drugs that would overcome cisplatin resistance. Replacement of the ammine group in antitumor cisplatin by a heterocyclic ligand (piperidine, piperazine, or 4-picoline) results in reduction of cytotoxicity in human ovarian cancer cells. The results suggest that in certain cancer cells the lower cytotoxicity of cis-[PtCl2(NH3)(piperidine)] might be partially associated with reduced affinity of the high mobility group proteins to the major intrastrand cross-links of this analogue relative to the same adducts of cisplatin. The results support the view that the concept based on the design of the complexes structurally derived from cisplatin that do not present an altered DNA binding mode may be less effective in the search for new platinum drugs that would overcome cisplatin resistance. (en)
Title	Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues. Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues. (en)
skos:prefLabel	Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues. Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues. (en)
skos:notation	RIV/68081707:_____/03:17033049!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	1424;1432
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/1552), P(IBS5004009), P(KJB5004301), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Nováková, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	605271
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033049
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; piperidine ligand; antitumor cisplatin analogues (en)
http://linked.open.../riv/klicoveSlovo	DNA piperidine ligand antitumor cisplatin analogues
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9D83C108EA49]
http://linked.open...i/riv/nazevZdroje	Chemical Research in Toxicology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Untraditional therapeutic approaches in oncology Molecular mechanisms underlying anticancer effects of a new drug BBR3464
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Nováková, Olga Gibson, D. Najajreh, Y. Perez, J.-M.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0893-228X
number of pages	9 (xsd:int)

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