About: Plant Ribonucleases and Nucleases as Antiproliferative Agens Targeting Human Tumors Growing in Mice

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recombinant plant nucleases of tomato (TBN1) and hop (HBN1) (submitted to patenting under no. PV 2008-384;Z7585) were isolated to homogeneity and examined for their antitumor effects and cytotoxicity. Although antiproliferative effects of both recombinant nucleases were not significant on the ML-2 cell culture in vitro, the nucleases were strongly cytostatic in vivo after their administration intravenously as stabilized conjugates with polyethylene glycol (PEG). However, the antitumor effect of the first nuclease tested, the mung bean nuclease (PhA), on ML2 human tumor cell line was neither effective, even when significant antitumor activity was detected on human melanoma tumors in vivo. Recombinant TBN1 and HBN1 were as effective against human melanoma tumors as previously studied pine pollen nuclease and PhA and their effects were reached at about ten times lower concentrations compared to the use of bovine seminal RNase (BS-RNase). Recombinant plant nucleases of tomato (TBN1) and hop (HBN1) (submitted to patenting under no. PV 2008-384;Z7585) were isolated to homogeneity and examined for their antitumor effects and cytotoxicity. Although antiproliferative effects of both recombinant nucleases were not significant on the ML-2 cell culture in vitro, the nucleases were strongly cytostatic in vivo after their administration intravenously as stabilized conjugates with polyethylene glycol (PEG). However, the antitumor effect of the first nuclease tested, the mung bean nuclease (PhA), on ML2 human tumor cell line was neither effective, even when significant antitumor activity was detected on human melanoma tumors in vivo. Recombinant TBN1 and HBN1 were as effective against human melanoma tumors as previously studied pine pollen nuclease and PhA and their effects were reached at about ten times lower concentrations compared to the use of bovine seminal RNase (BS-RNase). (en)
Title	Plant Ribonucleases and Nucleases as Antiproliferative Agens Targeting Human Tumors Growing in Mice Plant Ribonucleases and Nucleases as Antiproliferative Agens Targeting Human Tumors Growing in Mice (en)
skos:prefLabel	Plant Ribonucleases and Nucleases as Antiproliferative Agens Targeting Human Tumors Growing in Mice Plant Ribonucleases and Nucleases as Antiproliferative Agens Targeting Human Tumors Growing in Mice (en)
skos:notation	RIV/67985904:_____/10:00340102!RIV10-AV0-67985904
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA521/06/1149), P(GA521/09/1214), Z(AV0Z50450515), Z(AV0Z50510513)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Matoušek, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	279088
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/10:00340102
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antiproliferative cytotoxic; effect human; plant nuclease (en)
http://linked.open.../riv/klicoveSlovo	antiproliferative cytotoxic effect human plant nuclease
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[FEB83C187495]
http://linked.open...i/riv/nazevZdroje	Recent Patents on DNA & Gene Sequences
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Modification and in planta production of bifunctional nucleases and analysis of their anticancerogenic and biological activities Molecular analysis of plant nuclease homologues and their antitumor potential in comparison with animal ribonucleases
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Matoušek, Jaroslav Matoušek, Josef
http://linked.open...n/vavai/riv/zamer	Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture Výzkum struktury genetické informace rostlin a jejich patogenů na molekulární úrovni, indukce a analýza cílených změn genomu a plastomu a studium fotosyntetických procesů a projevů dědičnosti v interakci s prostředím a patogeny
issn	1872-2156
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Plant Ribonucleases and Nucleases as Antiproliferative Agens Targeting Human Tumors Growing in Mice Plant Ribonucleases and Nucleases as Antiproliferative Agens Targeting Human Tumors Growing in Mice Plant Ribonucleases and Nucleases as Antiproliferative Agens Targeting Human Tumors Growing in Mice

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