About: Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension.

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About: Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHR. However, the role of Cd36 and chromosome 4 in the control of blood pressure (BP) and systemic cardiovascular risk factors in SHR is unknown. In the SHR.BN-Il6/Npy congenic strain, we have found that transfer of a single segment of chromosome 4 including Cd36 from the normotensive Brown Norway (BN) rat onto the SHR background induces reductions in systolic BP and ameliorates dietary induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. These results demonstrate that a single chromosome region can influence the entire spectrum of systemic cardiovascular risk factors that constitute the hypertension metabolic syndrome. A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHR. However, the role of Cd36 and chromosome 4 in the control of blood pressure (BP) and systemic cardiovascular risk factors in SHR is unknown. In the SHR.BN-Il6/Npy congenic strain, we have found that transfer of a single segment of chromosome 4 including Cd36 from the normotensive Brown Norway (BN) rat onto the SHR background induces reductions in systolic BP and ameliorates dietary induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. These results demonstrate that a single chromosome region can influence the entire spectrum of systemic cardiovascular risk factors that constitute the hypertension metabolic syndrome. (en)
Title	Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension. Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension. (en)
skos:prefLabel	Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension. Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension. (en)
skos:notation	RIV/67985823:_____/99:20010217!RIV/2003/AV0/A20003/N
http://linked.open.../vavai/riv/strany	1651;1657
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA306/97/0521), P(GV204/98/K015), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Zídek, Václav Šimáková, Miroslava Pravenec, Michal Křen, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	741269
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/99:20010217
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cd36; - cardiovascular risk factors; - spontaneous hypertension (en)
http://linked.open.../riv/klicoveSlovo	Cd36 - cardiovascular risk factors - spontaneous hypertension
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3FB8B9392D8D]
http://linked.open...i/riv/nazevZdroje	Journal of Clinical Investigation
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic and correlation analysis of a complex metabolic syndrome in spontaneously hypertensive rats Molecular mapping of the mammalian genome and positional cloning of mammalian genes
http://linked.open...UplatneniVysledku	1999
http://linked.open...v/svazekPeriodika	103
http://linked.open...iv/tvurceVysledku	Kazdová, L. Křen, Vladimír Kurtz, T. W. Pravenec, Michal Zídek, Václav Aitman, T. J. Yang, Y. Horký, K. Jáchymová, M. Míková, B. Churchill, P. C. Křenová, D. Wang, J. M. Zdobinská, Miroslava Hingarh, N. H. St. Lezin, E. M. Webb, R. C.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0021-9738
number of pages	7 (xsd:int)

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