About: Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status

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About: Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We studied the effect of regeneration, altered innervation and thyroid hormone levels on fiber type transitions in slow soleus (SOL) muscles grafted (GRAFT) into host extensor digitorum longus (EDLh) muscles of euthyroid (EU), hyperthyroid (HT) and hypothyroid (HY) Lewis strain rats. SOL muscles were excised from 3- to 4-week-old inbred Lewis rats and intramuscularly transplanted into EDLh muscles of 2-month-old female rats of the same strain. The transition towards fast muscle phenotype was more pronounced in HT status, where the fastest type 2B fibers predominated. On the contrary, in HY status, the slow to fast transformation was less pronounced, as GRAFT contained less type 2B and 2X but more type 2A and 1 fibers. We conclude that the type of innervation is the crucial factor for the slow to fast fiber type transitions in GRAFT, but the extent of muscle transformation is further modulated by altered TH status We studied the effect of regeneration, altered innervation and thyroid hormone levels on fiber type transitions in slow soleus (SOL) muscles grafted (GRAFT) into host extensor digitorum longus (EDLh) muscles of euthyroid (EU), hyperthyroid (HT) and hypothyroid (HY) Lewis strain rats. SOL muscles were excised from 3- to 4-week-old inbred Lewis rats and intramuscularly transplanted into EDLh muscles of 2-month-old female rats of the same strain. The transition towards fast muscle phenotype was more pronounced in HT status, where the fastest type 2B fibers predominated. On the contrary, in HY status, the slow to fast transformation was less pronounced, as GRAFT contained less type 2B and 2X but more type 2A and 1 fibers. We conclude that the type of innervation is the crucial factor for the slow to fast fiber type transitions in GRAFT, but the extent of muscle transformation is further modulated by altered TH status (en)
Title	Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status (en)
skos:prefLabel	Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status (en)
skos:notation	RIV/67985823:_____/14:00436413!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7AMB14SK123), P(GA304/08/0256), P(LH12058)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Soukup, Tomáš Zachařová, Gisela Kopecká, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	45352
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00436413
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	muscle fiber types; muscle regeneration; muscle transplantation; MyHC isoforms; thyroid hormone status (en)
http://linked.open.../riv/klicoveSlovo	muscle fiber types muscle transplantation MyHC isoforms muscle regeneration thyroid hormone status
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[8538EC515951]
http://linked.open...i/riv/nazevZdroje	Histochemistry and Cell Biology
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Investigation of the cardioprotection using n-3 PUFA against injury and malignant arrhythmias induced by altered thyroid status. Regulation of muscle phenotype under normal, experimental and pathological conditions Mechanisms of Neuropathic Pain States
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	142
http://linked.open...iv/tvurceVysledku	Soukup, Tomáš Kopecká, Kateřina Zachařová, Gisela Smerdu, V.
http://linked.open...ain/vavai/riv/wos	000346930200007
issn	0948-6143
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00418-014-1247-5

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