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rdf:type
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Description
| - We investigated here whether n-3 LC-PUFA could elicit additive beneficial effects on metabolic flexibility when combined with a TZD drug rosiglitazone in mice. Metabolomic and gene expression analyses in the muscle suggested distinct and complementary effects of the interventions, with n-3 LC-PUFA supporting complete oxidation of fatty acids in mitochondria and the combination with n-3 LC-PUFA and rosiglitazone augmenting insulin sensitivity by the modulation of branched-chain amino acid metabolism. These beneficial metabolic effects were associated with the activation of the switch between glycolytic and oxidative muscle fibers, especially in mice fed combined diet of n-3 LC-PUFA and rosiglitazone
- We investigated here whether n-3 LC-PUFA could elicit additive beneficial effects on metabolic flexibility when combined with a TZD drug rosiglitazone in mice. Metabolomic and gene expression analyses in the muscle suggested distinct and complementary effects of the interventions, with n-3 LC-PUFA supporting complete oxidation of fatty acids in mitochondria and the combination with n-3 LC-PUFA and rosiglitazone augmenting insulin sensitivity by the modulation of branched-chain amino acid metabolism. These beneficial metabolic effects were associated with the activation of the switch between glycolytic and oxidative muscle fibers, especially in mice fed combined diet of n-3 LC-PUFA and rosiglitazone (en)
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Title
| - Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice
- Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice (en)
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skos:prefLabel
| - Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice
- Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice (en)
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skos:notation
| - RIV/67985823:_____/12:00380295!RIV13-GA0-67985823
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(7E10059), P(GA303/08/0664)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
| - Kopecký, Jan
- Flachs, Pavel
- Hensler, Michal
- Bardová, Kristina
- Kůs, Vladimír
- Rossmeisl, Martin
- Kuda, Ondřej
- Janovská, Petra
- Horáková, Olga
- Medříková, Daša
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/12:00380295
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - n-3 LC-PUFA; TZD; muscle insulin sensitivity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kopecký, Jan
- Medříková, Daša
- Bardová, Kristina
- Flachs, Pavel
- Hensler, Michal
- Kůs, Vladimír
- Janovská, Petra
- Kuda, Ondřej
- Rossmeisl, Martin
- Illig, T.
- Wang-Sattler, R.
- Horáková, Olga
- Keijer, J.
- van Schothorst, E. M.
- Adamski, J.
- Bunschoten, A.
- Prehn, C.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1371/journal.pone.0043764
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is http://linked.open...avai/riv/vysledek
of | |