About: Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Strategies to prevent and treat obesity aim to decrease energy intake and/or increase energy expenditure. Thus, ectopic expression of brown fat-specific mitochondrial uncoupling protein 1 (UCP1) elicited major metabolic effects both at the cellular/tissue level and at the whole-body level. The consequences of mitochondrial uncoupling in WAT and SM are not identical, showing robust and stable obesity resistance accompanied by improvement of lipid metabolism in the case of ectopic UCP1 in WAT, while preservation of insulin sensitivity in the context of high-fat feeding represents the major outcome of muscle UCP1 expression. These complex responses could be largely explained by tissue-specific activation of AMPK, triggered by a depression of cellular energy charge Strategies to prevent and treat obesity aim to decrease energy intake and/or increase energy expenditure. Thus, ectopic expression of brown fat-specific mitochondrial uncoupling protein 1 (UCP1) elicited major metabolic effects both at the cellular/tissue level and at the whole-body level. The consequences of mitochondrial uncoupling in WAT and SM are not identical, showing robust and stable obesity resistance accompanied by improvement of lipid metabolism in the case of ectopic UCP1 in WAT, while preservation of insulin sensitivity in the context of high-fat feeding represents the major outcome of muscle UCP1 expression. These complex responses could be largely explained by tissue-specific activation of AMPK, triggered by a depression of cellular energy charge (en)
Title	Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase (en)
skos:prefLabel	Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase (en)
skos:notation	RIV/67985823:_____/12:00377925!RIV13-MZ0-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(7E10059), P(NS10528), P(OC08008), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kopecký, Jan Rossmeisl, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	124098
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00377925
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adipose tissue; skeletal muscle; uncoupling protein; transgenic mice; insulin sensitivity (en)
http://linked.open.../riv/klicoveSlovo	uncoupling protein insulin sensitivity transgenic mice adipose tissue skeletal muscle
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F99C6252DCE1]
http://linked.open...i/riv/nazevZdroje	Genes and Nutrition
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Aditive effects of omega-3 polyunsaturated fatty acids and pioglitazone in the treatment of type 2 diabetes mellitus Biomarkets of Robustness of Metabolic - Hoemostasis for nutrigenomics - derived Health claims made on food Modulation of metabolism by omega 3 fatty acids
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Kopecký, Jan Rossmeisl, Martin Keipert, S. Klaus, S.
http://linked.open...ain/vavai/riv/wos	000305522100002
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1555-8932
number of pages	18 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s12263-011-0260-8
is http://linked.open...avai/riv/vysledek of	Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase

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