About: Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension

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About: Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The present study was undertaken to evaluate the effects of chronic treatment with c-AUCB, a novel inhibitor of soluble epoxide hydrolase (sEH) which is responsible for the conversion of biologically active epoxyeicosatrienoic acids to biologically inactive dihydroxyeicosatrienoic acids, on blood pressure and myocardial infarct size in male heterozygous Ren-2 transgenic rats with established hypertension. Our findings indicate that chronic inhibition of sEH exhibits antihypertensive and cardioprotective actions in this transgenic model of angiotensin II-dependent hypertension The present study was undertaken to evaluate the effects of chronic treatment with c-AUCB, a novel inhibitor of soluble epoxide hydrolase (sEH) which is responsible for the conversion of biologically active epoxyeicosatrienoic acids to biologically inactive dihydroxyeicosatrienoic acids, on blood pressure and myocardial infarct size in male heterozygous Ren-2 transgenic rats with established hypertension. Our findings indicate that chronic inhibition of sEH exhibits antihypertensive and cardioprotective actions in this transgenic model of angiotensin II-dependent hypertension (en)
Title	Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension (en)
skos:prefLabel	Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension (en)
skos:notation	RIV/67985823:_____/12:00377329!RIV13-AV0-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0510), P(IAAX01110901), P(KAN200520703), P(NS10499), P(NS9699), P(NS9703), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Papoušek, František Kolář, František Ošťádal, Bohuslav Neckář, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	141858
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00377329
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hypertension; angiotensin II; kidney; epoxyeicosatrienoic acids; soluble epoxide hydrolase inhibitor; myocardial ischemia/reperfusion injury (en)
http://linked.open.../riv/klicoveSlovo	epoxyeicosatrienoic acids angiotensin II hypertension - ischaemic heart disease - cardiac failure - vitamin D myocardial ischemia/reperfusion injury soluble epoxide hydrolase inhibitor kidney
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[5970F2CE2D65]
http://linked.open...i/riv/nazevZdroje	Clinical science
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	The use of ultrasound in nanomedicine The role of adrenergic signaling and oxidative stress in molecular mechanisms of cardioprotection induced by chronic hypoxia The role of increased epoxyeicosatrienoic acids level in the regulation of renal function and pathophysiology of renovascular hypertension Novel approach to blood pressure control and organ protection- intervention to renin-angiotensin and endothelin systems Centre for cardiovascular research The role of impairment of pressure-natriuresis mechanism in the pathophysiology of angiotensin II-dependent malignant form of hypertension
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	122
http://linked.open...iv/tvurceVysledku	Neckář, Jan Kolář, František Malý, J. Červenka, L. Papoušek, František Netuka, I. Ošťádal, Bohuslav Imig, J. D. Kramer, H. J. Husková, Z. Hammock, B. D. Hwang, S. H. Kopkan, L.
http://linked.open...ain/vavai/riv/wos	000304891200002
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0143-5221
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1042/CS20110622
is http://linked.open...avai/riv/vysledek of	Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension

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