About: Synthesis of novel azanorbornylpurine derivatives

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Novel racemic derivatives of 6-chloropurine, adenine, and 6-(cyclopropylamino)purine substituted with 2-azanorbornane, 7-azanorbornane, and 7-azabenzonorbornane were synthesized. All target compounds were tested for antiviral activity (CVB3, HCV) and 6-chloropurine derivatives were evaluated for potential activity as agonists of the neuronal and muscle nicotinic acetylcholine receptor. Novel racemic derivatives of 6-chloropurine, adenine, and 6-(cyclopropylamino)purine substituted with 2-azanorbornane, 7-azanorbornane, and 7-azabenzonorbornane were synthesized. All target compounds were tested for antiviral activity (CVB3, HCV) and 6-chloropurine derivatives were evaluated for potential activity as agonists of the neuronal and muscle nicotinic acetylcholine receptor. (en)
Title	Synthesis of novel azanorbornylpurine derivatives Synthesis of novel azanorbornylpurine derivatives (en)
skos:prefLabel	Synthesis of novel azanorbornylpurine derivatives Synthesis of novel azanorbornylpurine derivatives (en)
skos:notation	RIV/67985823:_____/12:00376064!RIV13-GA0-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(GA202/09/0806), P(LC554), Z(AV0Z40550506), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kaniaková, Martina Krůšek, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	172973
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00376064
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	azanorbornane; purines; coxsackievirus (en)
http://linked.open.../riv/klicoveSlovo	coxsackievirus purines azanorbornane
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[CBF2E990B2B2]
http://linked.open...i/riv/nazevZdroje	Tetrahedron
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Neuroscience Centre Cooperativity of nicotinic receptors
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	68
http://linked.open...iv/tvurceVysledku	Dračínský, Martin Dejmek, Milan Hřebabecký, Hubert Leyssen, P. Nencka, Radim Neyts, J. Kaniaková, Martina Krůšek, Jan Šála, Michal
http://linked.open...ain/vavai/riv/wos	000300028800043
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0040-4020
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.tet.2011.11.035
is http://linked.open...avai/riv/vysledek of	Synthesis of novel azanorbornylpurine derivatives

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