About: Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization

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About: Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization Goto Sponge NotDistinct Permalink

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Description	Here we analyzed hormone-induced Ca2plus responses and the process of desenzitization in HEK 293 cells, which express endogenous angiotensin II receptor. These cells were transfected to express also high levels of TRH receptors or both TRH receptors and G11alpha protein. It might be concluded that the level of expression of G-protein-coupled receptors and their cognate G-proteins strongly influences not only the magnitude of cellular response but also the process of desensitization and resilience of transmembrane signaling mediated by these receptors to changes in the plasma membrane structure caused by cholesterol depletion Here we analyzed hormone-induced Ca2plus responses and the process of desenzitization in HEK 293 cells, which express endogenous angiotensin II receptor. These cells were transfected to express also high levels of TRH receptors or both TRH receptors and G11alpha protein. It might be concluded that the level of expression of G-protein-coupled receptors and their cognate G-proteins strongly influences not only the magnitude of cellular response but also the process of desensitization and resilience of transmembrane signaling mediated by these receptors to changes in the plasma membrane structure caused by cholesterol depletion (en) V této práci jsme analyzovali Ca2plus odpovědi vyvolané hormonem a proces desenzitizace v buňkách HEK 293, které přirozeně exprimují receptor pro angiotensin II. Tyto buňky byly transfekovány pro expresi vysokých hladin TRH receptoru nebo TRH receptoru spolu s G11alpha proteinem. Z našich experimentů může být učiněn závěr, že úroveň exprese TRH receptoru a s ním spřaženého G proteinu výrazně ovlivňuje nejen velikost odpovědi, ale také proces desenzitizace a citlivost transmembránové signalizace zprostředkované těmito receptory na změny v integritě plasmatické membrány způsobené odstraněním cholesterolu (cs)
Title	Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization (en) Vapníková odpověď na thyroliberin a angiotensin II: Úloha integrity plasmatické membrány a efekt overexprese G11-alpha proteinu v homologní a heterologní desensitizaci (cs)
skos:prefLabel	Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization (en) Vapníková odpověď na thyroliberin a angiotensin II: Úloha integrity plasmatické membrány a efekt overexprese G11-alpha proteinu v homologní a heterologní desensitizaci (cs)
skos:notation	RIV/67985823:_____/08:00320702!RIV09-AV0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/06/0121), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Svoboda, Petr Krůšek, Jan Durchánková, Dana Ostašov, Pavel Novotný, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	358962
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/08:00320702
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	calcium response; cholesterol depletion; desensitization (en)
http://linked.open.../riv/klicoveSlovo	cholesterol depletion desensitization calcium response
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0A6616702CE9]
http://linked.open...i/riv/nazevZdroje	Cell Biochemistry and Function
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Neuroscience Centre Subcellular distribution of mu- and delta-opioid receptors and functional activity of trimeric G proteins after the long-term morphine stimulation.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Novotný, Jiří Svoboda, Petr Krůšek, Jan Ostašov, Pavel Durchánková, Dana
http://linked.open...ain/vavai/riv/wos	254679300019
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0263-6484
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization

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