About: Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification

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About: Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Exprese transgenního resistinu v tukové tkáni SHR potkanů byla asociována s významným zvýšením poměru NEMK/glycerol při adrenalinem stimulované lipolýze. Transgenní SHR potkani měli významně redukovanou reesterifikaci NEMK v tukové tkáni. Tyto výsledky naznačují, že by prodiabetické účinky transgenního resistinu mohly být částečně zprostředkovány zvýšenou sekrecí NEMK z tukové tkáně v důsledku redukované reesterifikace NEMK v adipocytech (cs) A moderate expression of transgenic resistin in adipose tissue in the SHR was associated with significantly increased FFA/glycerol ratio during adrenaline stimulated lipolysis. Transgenic SHR also exhibited a significant decrease in FFA reesterification in adipose tissue. These findings raise the possibility that the prodiabetic effects of transgenic resistin may be partly mediated by increased FFA release from adipose tissue due to impaired FFA reesterification in adipocytes A moderate expression of transgenic resistin in adipose tissue in the SHR was associated with significantly increased FFA/glycerol ratio during adrenaline stimulated lipolysis. Transgenic SHR also exhibited a significant decrease in FFA reesterification in adipose tissue. These findings raise the possibility that the prodiabetic effects of transgenic resistin may be partly mediated by increased FFA release from adipose tissue due to impaired FFA reesterification in adipocytes (en)
Title	Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification Transgenní exprese resistinu v tukové tkáni spontánně hypertenzních potkanů redukuje reesterifikaci mastných kyselin (cs) Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification (en)
skos:prefLabel	Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification Transgenní exprese resistinu v tukové tkáni spontánně hypertenzních potkanů redukuje reesterifikaci mastných kyselin (cs) Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification (en)
skos:notation	RIV/67985823:_____/06:00040435!RIV07-MZ0-67985823
http://linked.open.../vavai/riv/strany	1157;1159
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0520), P(GA301/03/0751), P(NB7403), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Zídek, Václav Mlejnek, Petr Šimáková, Miroslava Landa, Vladimír Pravenec, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	475629
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/06:00040435
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	spontaneously hypertensive rat; transgenic resistin; fatty acid reesterification (en)
http://linked.open.../riv/klicoveSlovo	spontaneously hypertensive rat fatty acid reesterification transgenic resistin
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1E0B39BAAADD]
http://linked.open...i/riv/nazevZdroje	International Journal of Obesity
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Applied Genomics Transgenic analysis of the resistin effects on cyrbohydrate and lipid metabolism in spontaneously hypertensive rats The role of resistin and trascription factor SREBP-1 in the pathogenesis of insulin resistance.
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Kazdová, L. Kurtz, T. W. Landa, Vladimír Mlejnek, Petr Pravenec, Michal Wang, J. Zídek, Václav Šimáková, Miroslava Cahová, M. Qi, N.
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0307-0565
number of pages	3 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification

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