About: Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR.

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About: Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study provides direct evidence that a gene or genes on chromosome Y contribute to the pathogenesis of spontaneous hypertension in the SHR strain. It was also demonstrated that transfer of the Y chromosome from the BN rat onto the SHR background exacerbates dietary-induced dyslipidemia in SHR. Thus, genetic variation in genes on the Y chromosome may contribute to variation in blood pressure and lipid levels and may influence the risk for cardiovascular disease. This study provides direct evidence that a gene or genes on chromosome Y contribute to the pathogenesis of spontaneous hypertension in the SHR strain. It was also demonstrated that transfer of the Y chromosome from the BN rat onto the SHR background exacerbates dietary-induced dyslipidemia in SHR. Thus, genetic variation in genes on the Y chromosome may contribute to variation in blood pressure and lipid levels and may influence the risk for cardiovascular disease. (en)
Title	Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. (en)
skos:prefLabel	Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. (en)
skos:notation	RIV/67985823:_____/01:20010183!RIV/2003/AV0/A20003/N
http://linked.open.../vavai/riv/strany	1147;1152
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/00/1646), P(GV204/98/K015), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Zídek, Václav Pravenec, Michal Křen, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	702372
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/01:20010183
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	genetic hypertension; - spontaneously hypertensive rats; - cardiovascular disease (en)
http://linked.open.../riv/klicoveSlovo	genetic hypertension - cardiovascular disease - spontaneously hypertensive rats
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[937443649547]
http://linked.open...i/riv/nazevZdroje	Hypertension
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mapping and positional cloning of genes that are responsible for clustering of cardiovascular risk factors Molecular mapping of the mammalian genome and positional cloning of mammalian genes
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	37
http://linked.open...iv/tvurceVysledku	Křen, Vladimír Pravenec, Michal Zídek, Václav Horký, K. Jáchymová, M. Míková, B. Qi, N. Křenová, D. St. Lezin, E. Sladká, M. Van Lith, H. A. Van Zutphen, B. F. Bonne, A. Lau, Y. F. C.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0194-911X
number of pages	6 (xsd:int)

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