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rdf:type
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Description
| - Several groups including ours demonstrated cardiac hyperplasia in neonates from genetically hypertensive rat strains. Using recombinant inbred strains derived from a cross between Brown Norway and SHR progenitors, we mapped the inhibition of neonatal apoptosis to distinct loci on chromosome 1 and 18. The study has also demonstrated that the loci determining organ weights in neonates are distinct from those determining increased organ weight in adults. These studies suggest that cardiovascular cells from hypertensive animals are subject to accelerated turnover, potentially leading to their accelerated aging
- Several groups including ours demonstrated cardiac hyperplasia in neonates from genetically hypertensive rat strains. Using recombinant inbred strains derived from a cross between Brown Norway and SHR progenitors, we mapped the inhibition of neonatal apoptosis to distinct loci on chromosome 1 and 18. The study has also demonstrated that the loci determining organ weights in neonates are distinct from those determining increased organ weight in adults. These studies suggest that cardiovascular cells from hypertensive animals are subject to accelerated turnover, potentially leading to their accelerated aging (en)
- Některé skupiny včetně naší demonstrovaly srdeční hyperplazii u novorozenců geneticky hypertenzivních potkanů. Pomocí rekombinantních inbredních kmenů odvozených od Brown Norway a SHR rodičů jsme mapovali úseky na chromozómu 1 a 18, které mohou inhibovat neonatální apoptozu. Studie také ukázala, že chromozomální úseky determinující hmotnost orgánů u novorozenců jsou jiné než u dospělých zvířat. Tyto výsledky naznačují, že kardiovaskulární buňky z hypertenzivních zvířat jsou vystaveny zrychlenému životnímu cyklu, což může vést k urychlenému stárnutí těchto buněk (cs)
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Title
| - Nadměrný růst a apoptoza: Je hypertenze případ urychleného stárnutí kardiovaskulárních buněk? (cs)
- Excess growth and apoptosis: is hypertension a case of accelerated aging of cardiovascular cells?
- Excess growth and apoptosis: is hypertension a case of accelerated aging of cardiovascular cells? (en)
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skos:prefLabel
| - Nadměrný růst a apoptoza: Je hypertenze případ urychleného stárnutí kardiovaskulárních buněk? (cs)
- Excess growth and apoptosis: is hypertension a case of accelerated aging of cardiovascular cells?
- Excess growth and apoptosis: is hypertension a case of accelerated aging of cardiovascular cells? (en)
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skos:notation
| - RIV/67985823:_____/01:00142123!RIV07-AV0-67985823
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/01:00142123
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - hypertension; genetics (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Křen, Vladimír
- Kuneš, Jaroslav
- Pravenec, Michal
- Sun, Y.
- Hamet, P.
- Tremblay, J.
- Moreau, P.
- Dumas, P.
- Tea, B. S.
- Thorin-Trescases, N.
- deBlois, D.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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