About: Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry

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About: Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Proteins of glutamatergic NMDA receptor signaling pathways have been studied as targets for intervention in a variety of neuropathological conditions, including neurodegenerations, epilepsy, neuropathic pain, drug addiction, and schizophrenia. High activity NMDA-blocking agents have been designed to treat some of these disorders; however, their effect is often compromised by undesirable side effects. Therefore, alternative ways of modulating NMDA receptor function need to be sought after. Proteins of glutamatergic NMDA receptor signaling pathways have been studied as targets for intervention in a variety of neuropathological conditions, including neurodegenerations, epilepsy, neuropathic pain, drug addiction, and schizophrenia. High activity NMDA-blocking agents have been designed to treat some of these disorders; however, their effect is often compromised by undesirable side effects. Therefore, alternative ways of modulating NMDA receptor function need to be sought after. (en)
Title	Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry (en)
skos:prefLabel	Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry (en)
skos:notation	RIV/67179843:_____/11:00370154!RIV12-AV0-67179843
http://linked.open...avai/predkladatel	Centrum výzkumu globální změny AV ČR v.v.i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0508), P(GA203/08/0114), Z(AV0Z40550506), Z(AV0Z60870520)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Ettrich, Rüdiger
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Centrum výzkumu globální změny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	204843
http://linked.open...ai/riv/idVysledku	RIV/67179843:_____/11:00370154
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	amino acid analogs; L-erythro-3-hydroxyaspartate (L-EHA); D-serine; neurodegenerative diseases; NMDA receptors; pyridoxal-5´-phosphate (PLP) (en)
http://linked.open.../riv/klicoveSlovo	D-serine L-erythro-3-hydroxyaspartate (L-EHA) NMDA receptors amino acid analogs neurodegenerative diseases pyridoxal-5´-phosphate (PLP)
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[1343C504EE59]
http://linked.open...i/riv/nazevZdroje	Current Drug Targets
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Specific ion effects for proteins in solutions and related biologically relevant systems.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Ettrich, Rüdiger Jansa, Petr Konvalinka, Jan Lepšík, Martin Hoffman, Hillary Elizabeth Jirásková-Vaníčková, Jana Vorlová, Barbora
http://linked.open...ain/vavai/riv/wos	000291640900010
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Spatial and functional dynamics of biological, ecological and socio-economic systems interacting with global climatic change
issn	1389-4501
number of pages	19 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry

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